Ms4a1 Antibody (PACO28394)
- SKU:
- PACO28394
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Ms4a1 Antibody (PACO28394) |
| Antibody SKU: | PACO28394 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse B-lymphocyte antigen CD20 protein (111-291AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Ms4a1 antibody at 4µg/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Lane 4: HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 32 kDa Observed band size: 32 kDa . |
| Background: | This protein may be involved in the regulation of B-cell activation and proliferation. |
| Synonyms: | B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20), Ms4a1, Cd20 Ly-44 Ms4a2 |
| UniProt Protein Function: | MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19 A|19 8.19 cMCellular Component: external side of plasma membrane; extracellular exosome; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membraneMolecular Function: epidermal growth factor receptor binding; protein bindingBiological Process: B cell activation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P19437 |
| NCBI GenInfo Identifier: | 6671710 |
| NCBI Gene ID: | 12482 |
| NCBI Accession: | NP_031667.1 |
| UniProt Secondary Accession: | P19437 |
| UniProt Related Accession: | P19437 |
| Molecular Weight: | 31,958 Da |
| NCBI Full Name: | B-lymphocyte antigen CD20 |
| NCBI Synonym Full Names: | membrane-spanning 4-domains, subfamily A, member 1 |
| NCBI Official Symbol: | Ms4a1 |
| NCBI Official Synonym Symbols: | Cd20; Ly-44; Ms4a2; AA960661 |
| NCBI Protein Information: | B-lymphocyte antigen CD20 |
| UniProt Protein Name: | B-lymphocyte antigen CD20 |
| UniProt Synonym Protein Names: | B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20 |
| Protein Family: | CD209 antigen |
| UniProt Gene Name: | Ms4a1 |
| UniProt Entry Name: |
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