MRPL21 Antibody (PACO37426)
- SKU:
- PACO37426
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MRPL21 Antibody (PACO37426) |
| Antibody SKU: | PACO37426 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human 39S ribosomal protein L21, mitochondrial protein (40-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO37426 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO37426 at dilution of 1:100. |
| Background: | mitochondrial inner membrane, mitochondrial large ribosomal subunit, poly(A) RNA binding, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational initiation, mitochondrial translational termination, organelle organization |
| Synonyms: | 39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21) (Mitochondrial large ribosomal subunit protein bL21m), MRPL21 |
| UniProt Protein Function: | MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z2W9 |
| NCBI GenInfo Identifier: | 31652228 |
| NCBI Gene ID: | 219927 |
| NCBI Accession: | NP_852616.1 |
| UniProt Secondary Accession: | Q7Z2W9,A6NKU0, C9JPR2 |
| UniProt Related Accession: | Q7Z2W9 |
| Molecular Weight: | 13,746 Da |
| NCBI Full Name: | 39S ribosomal protein L21, mitochondrial isoform a |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L21 |
| NCBI Official Symbol: | MRPL21 |
| NCBI Official Synonym Symbols: | L21mt; MRP-L21 |
| NCBI Protein Information: | 39S ribosomal protein L21, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L21, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL21 |
| UniProt Entry Name: | RM21_HUMAN |
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