MRGPRX2 Antibody (PACO38746)
- SKU:
- PACO38746
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MRGPRX2 Antibody (PACO38746) |
| Antibody SKU: | PACO38746 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Mas-related G-protein coupled receptor member X2 protein (286-330AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MRGPRX2 antibody at 5µg/ml. Lane 1: 293T whole cell lysate. Lane 2: Mouse liver tissue. Lane 3: MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 38 kDa. Observed band size: 38 kDa. |
 | Immunofluorescent analysis of MCF-7 cells using PACO38746 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. |
| Synonyms: | Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2 |
| UniProt Protein Function: | MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11p15.1Cellular Component: integral to membrane; integral to plasma membraneMolecular Function: G-protein coupled receptor activity; neuropeptide bindingBiological Process: mast cell activation; mast cell degranulation; positive regulation of cytokinesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96LB1 |
| NCBI GenInfo Identifier: | 50401127 |
| NCBI Gene ID: | 117194 |
| NCBI Accession: | Q96LB1.1 |
| UniProt Secondary Accession: | Q96LB1,Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4 Q4QXX6, Q4QXX7, B5B0C7 |
| UniProt Related Accession: | Q96LB1 |
| Molecular Weight: | 37,099 Da |
| NCBI Full Name: | Mas-related G-protein coupled receptor member X2 |
| NCBI Synonym Full Names: | MAS related GPR family member X2 |
| NCBI Official Symbol: | MRGPRX2 |
| NCBI Official Synonym Symbols: | MGRG3; MRGX2 |
| NCBI Protein Information: | mas-related G-protein coupled receptor member X2 |
| UniProt Protein Name: | Mas-related G-protein coupled receptor member X2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Mas-related G-protein coupled receptor |
| UniProt Gene Name: | MRGPRX2 |
| UniProt Entry Name: | MRGX2_HUMAN |
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