MRAP2 Antibody (PACO39834)
- SKU:
- PACO39834
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MRAP2 Antibody (PACO39834) |
| Antibody SKU: | PACO39834 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Melanocortin-2 receptor accessory protein 2 protein (66-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MRAP2 antibody at 7µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa. |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO39834 at dilution of 1:100. |
 | Immunofluorescent analysis of U251 cells using PACO39834 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. |
| Synonyms: | Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2), MRAP2, C6orf117 |
| UniProt Protein Function: | MRAP2: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Belongs to the MRAP family. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5RChromosomal Location of Human Ortholog: 6q14.2Cellular Component: endoplasmic reticulum; plasma membraneMolecular Function: adrenocorticotropin hormone receptor binding; identical protein binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor bindingBiological Process: energy reserve metabolic process; feeding behavior; positive regulation of cAMP biosynthetic processDisease: Body Mass Index Quantitative Trait Locus 18 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96G30 |
| NCBI GenInfo Identifier: | 68565259 |
| NCBI Gene ID: | 112609 |
| NCBI Accession: | Q96G30.2 |
| UniProt Secondary Accession: | Q96G30,Q8IXM9, Q8N2D1, A8K9M1 |
| UniProt Related Accession: | Q96G30 |
| Molecular Weight: | 23,548 Da |
| NCBI Full Name: | Melanocortin-2 receptor accessory protein 2 |
| NCBI Synonym Full Names: | melanocortin 2 receptor accessory protein 2 |
| NCBI Official Symbol: | MRAP2 |
| NCBI Official Synonym Symbols: | BMIQ18; C6orf117; bA51G5.2 |
| NCBI Protein Information: | melanocortin-2 receptor accessory protein 2 |
| UniProt Protein Name: | Melanocortin-2 receptor accessory protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Melanocortin-2 receptor accessory protein |
| UniProt Gene Name: | MRAP2 |
| UniProt Entry Name: | MRAP2_HUMAN |
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