MPHOSPH8 Antibody (PACO10553)
- SKU:
- PACO10553
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MPHOSPH8 Antibody (PACO10553) |
| Antibody SKU: | PACO10553 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human MPHOSPH8 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | M-phase phosphoprotein 8;MPHOSPH8;FLJ35237;HSMPP8;TWA3;mpp8 ; |
| UniProt Protein Function: | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q99549 |
| NCBI GenInfo Identifier: | 41055989 |
| NCBI Gene ID: | 54737 |
| NCBI Accession: | NP_059990.2 |
| UniProt Secondary Accession: | Q99549,Q5JPE5, Q5JTQ0, Q86TK3, Q96MK4, Q9BTP1, B7Z6F9 |
| UniProt Related Accession: | Q99549 |
| Molecular Weight: | 94 |
| NCBI Full Name: | M-phase phosphoprotein 8 |
| NCBI Synonym Full Names: | M-phase phosphoprotein 8 |
| NCBI Official Symbol: | MPHOSPH8 |
| NCBI Official Synonym Symbols: | TWA3; mpp8; HSMPP8 |
| NCBI Protein Information: | M-phase phosphoprotein 8 |
| UniProt Protein Name: | M-phase phosphoprotein 8 |
| UniProt Synonym Protein Names: | Two hybrid-associated protein 3 with RanBPM |
| Protein Family: | |
| UniProt Gene Name: | MPHOSPH8 |
| UniProt Entry Name: |
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