Mouse WIF1 Recombinant Protein (RPPB5936)
- SKU:
- RPPB5936
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9WUA1
Description
| Product Name: | Mouse WIF1 Recombinant Protein |
| Product Code: | RPPB5936 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | WIF1 |
| Synonyms: | Wntinhibitory factor 1, WIF-1, Wif1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | WIF1protein solution (1mg/ml) contains 20mM MES (pH5.5), 1mM DTT, 1mM PMSF and 30%glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% asdetermined by SDS-PAGE. |
| Amino Acid Sequence: | GQPPEESLYL WIDAHQARVL IGFEEDILIV SEGKMAPFTH DFRKAQQRMPAIPVNIHSMN FTWQAAGQAE YFYEFLSLRS LDKGIMADPT VNVPLLGTVP HKASVVQVGF PCLGKQDGVAAFEVNVIVMN SEGNTILRTP QNAIFFKTCQ QAECPGGCRN GGFCNERRVC ECPDGFYGPHCEKALCIPRC MNGGLCVTPGFCICPPGFYG VNCDKANCST TCFNGGTCFY PGKCICPPGL EGEQCELSKC PQPCRNGGKC IGKSKCKCPK GYQGDLCSKPVCEPGCGAHG TCHEPNKCQC REGWHGRHCN KRYGASLMHA PRPAGAGLER HTPSLKKAED RRDPPESNYI WVEHHHHHH |
WIF1 binds to wnt proteins and inhibits their activities. WIF1 plays a role in mesoderm segmentation. WNT proteins are extracellular signaling molecules that take part in the control of embryonic development & cancer. WIF1 protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WIF1 takes part in mesoderm segmentation. WIF1 protein is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 is a tumor suppressor, specifically in nonfunctioning pituitary tumors.
WIF1 produced in Sf9 Insect cells is a single,glycosylated polypeptide chain containing 359 amino acids (29-379a.a.) andhaving a molecular mass of 39.4kDa. (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).WIF1 is expressed with an 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WIF1: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.Protein type: Secreted; Inhibitor; Secreted, signal peptideCellular Component: extracellular regionMolecular Function: Wnt-protein bindingBiological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; multicellular organismal development; positive regulation of fat cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9WUA1 |
| NCBI GenInfo Identifier: | 6755999 |
| NCBI Gene ID: | 24117 |
| NCBI Accession: | NP_036045.1 |
| UniProt Secondary Accession: | Q9WUA1 |
| UniProt Related Accession: | Q9WUA1 |
| Molecular Weight: | 41,590 Da |
| NCBI Full Name: | wnt inhibitory factor 1 |
| NCBI Synonym Full Names: | Wnt inhibitory factor 1 |
| NCBI Official Symbol: | Wif1�� |
| NCBI Official Synonym Symbols: | WIF-1; AW107799�� |
| NCBI Protein Information: | wnt inhibitory factor 1 |
| UniProt Protein Name: | Wnt inhibitory factor 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Wnt inhibitory factor |
| UniProt Gene Name: | Wif1�� |
| UniProt Entry Name: | WIF1_MOUSE |
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