Mouse VCAM1 Recombinant Protein (RPPB5119)
- SKU:
- RPPB5119
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P29533
Description
| Product Name: | Mouse VCAM1 Recombinant Protein |
| Product Code: | RPPB5119 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | VCAM1 |
| Synonyms: | V-CAM1, VCAM-1, CD106, Vcam1, Vcam-1, Vascular cell adhesion protein 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | VCAM1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10%glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | FKIEISPEYK TIAQIGDSMA LTCSTTGCES PLFSWRTQID SPLNAKVRTEGSKSVLTMEP VSFENEHSYL CTATCGSGKL ERSIHVDIYS FPKDPEIQFS GPLEVGKPVT VKCLAPDIYPVYRLEIDLFK GDQLMNRQEF SSEEMTKSLE TKSLEVTFTP VIEDIGKALV CRAKLHIDQI DSTLKERETVKELQVYISPR NTTISVHPST RLQEGGAVTM TCSSEGLPAP EIFWGRKLDN EVLQLLSGNA TLTLIAMRMEDSGVYVCEGV NLIGRDKAEV ELVVQEKPFI VDISPGSQVA AQVGDSVVLT CAAIGCDSPS FSWRTQTDSP LNGVVRNEGA KSTLVLSSVGFEDEHSYLCA VTCLQRTLEK RTQVEVYSFP EDPVIKMSGP LVHGRPVTVN CTVPNVYPFD HLEIELLKGETTLMKKYFLE EMGIKSLETK ILETTFIPTI EDTGKSLVCL ARLHSGEMES EPKQRQSVQP LYVNVAPKETTIWVSPSPIL EEGSPVNLTC SSDGIPAPKI LWSRQLNNGE LQPLSENTTL TFMSTKRDDS GIYVCEGINEAGISRKSVEL IIQVSPKDIQ LTVFPSKSVK EGDTVIISCT CGNVPETWII LKKKAKTGDMVLKSVDGSYT IRQAQLQDAG IYECESKTEV GSQLRSLTLD VKGKEHNKNY FSPELEHHHH HH |
VCAM1 is a member of the Ig superfamily. It is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. VCAM-1 contains 6 or 7 immunoglobulin domains, and is expressed on both large and small vessels only after the endothelial cells are stimulated by cytokines. The protein has a number of functions including the regulation of leukocyte migration, leukocyte endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases (artherosclerosis and rheumatoid arthritis).
VCAM1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated� polypeptide chain containing 682 amino acids (25-698 a.a) and having a molecular mass of 75.4kDa (Migrates at 70-100kDa on SDS-PAGE under reducing conditions). VCAM1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3 G1|3 50.17 cM Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; microvillus; podosome; sarcolemma Molecular Function:amine oxidase activity; cell adhesion molecule binding; integrin binding Biological Process: amine metabolic process; cell adhesion; cell-matrix adhesion; heart development; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; positive regulation of T cell proliferation |
| UniProt Code: | P29533 |
| NCBI GenInfo Identifier: | 267283 |
| NCBI Gene ID: | 22329 |
| NCBI Accession: | P29533.1 |
| UniProt Related Accession: | P29533 |
| Molecular Weight: | 38,372 Da |
| NCBI Full Name: | Vascular cell adhesion protein 1 |
| NCBI Synonym Full Names: | vascular cell adhesion molecule 1 |
| NCBI Official Symbol: | Vcam1�� |
| NCBI Official Synonym Symbols: | CD106; Vcam-1�� |
| NCBI Protein Information: | vascular cell adhesion protein 1 |
| UniProt Protein Name: | Vascular cell adhesion protein 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD106 |
| Protein Family: | Vascular cell adhesion protein |
| UniProt Gene Name: | Vcam1�� |
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