Mouse UCHL1 Recombinant Protein (RPPB5077)
- SKU:
- RPPB5077
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9R0P9
Description
| Product Name: | Mouse UCHL1 Recombinant Protein |
| Product Code: | RPPB5077 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | UCHL1 |
| Synonyms: | Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1,Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UCHL1 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMQLKPME INPEMLNKVL AKLGVAGQWR FADVLGLEEE TLGSVPSPAC ALLLLFPLTA QHENFRKKQI EELKGQEVSP KVYFMKQTIG NSCGTIGLIH AVANNQDKLE FEDGSVLKQF LSETEKLSPE DRAKCFEKNE AIQAAHDSVA QEGQCRVDDK VNFHFILFNN VDGHLYELDG RMPFPVNHGA SSEDSLLQDA AKVCREFTER EQGEVRFSAV ALCKAA |
| Biological Activity: | Specific activity is > 70 pmol/min/ug, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of ubiquitin-AMC per minute at pH 7.5, at 37�C. |
UbiquitinCarboxyl-Terminal Esterase L1 (UCHL1) is a part of a family whose productshydrolyze small C-terminal adducts of ubiquitin to create the ubiquitin monomer.UCHL1 is a part of the ubiquitin system, which regulates many biologicalactivities. UCHL1 is a thiol protease that distinguishes and hydrolyzes apeptide bond at the C-terminal glycine of ubiquitin. UCHL1 binds to free monoubiquitinand avoids its degradation in lysosomes.
UCHL1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (1-223 a.a) and having a molecular mass of 27.2kDa.UCHL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. |
| UniProt Code: | Q9R0P9 |
| NCBI GenInfo Identifier: | 18203410 |
| NCBI Gene ID: | 22223 |
| NCBI Accession: | Q9R0P9.1 |
| UniProt Secondary Accession: | Q9R0P9,Q9R122, |
| UniProt Related Accession: | Q9R0P9 |
| Molecular Weight: | 24,838 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| NCBI Synonym Full Names: | ubiquitin carboxy-terminal hydrolase L1 |
| NCBI Official Symbol: | Uchl1�� |
| NCBI Official Synonym Symbols: | gad; C88048; PGP9.5; R75593; UCH-L1; UCHL-1; PGP 9.5; AW822034�� |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| UniProt Synonym Protein Names: | Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1 |
| UniProt Gene Name: | Uchl1�� |
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