Developmental Biology Recombinant Proteins
Mouse TrkB/NTRK2 Recombinant Protein (RPES3677)
- SKU:
- RPES3677
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Developmental Biology
Description
Mouse TrkB/NTRK2 Recombinant Protein
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Mouse TrkB/NTRK2 Recombinant Protein (RPES3677) |
| Product Code: | RPES3677 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | GP145-TrkB/GP95-TrkB,Tkrb,trk-B,trkB |
| Accession: | P15209-2 |
| Sequence: | Met 1-His 429 |
| Fusion tag: | C-His |
| Activity: | 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse/Human BDNF Protein (Native) at 10 µg/ml (100 ?l/well) can bind biotinylated mouse TrkB-His with a linear range of 10-80 ng/ml. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of mouse NTRK2 (P15209-2) (Met 1-His 429) was expressed, with a C-terminal polyhistidine tag. |
| Purity: | > 98 % as determined by SDS-PAGE |
| Mol Mass: | 46 kDa |
| AP Mol Mass: | 75-85 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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