Mouse TNF-alpha/TNFA Recombinant Protein (RPES4097)
- SKU:
- RPES4097
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse TNF-alpha/TNFA Recombinant Protein
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment. TNF-alpha Protein & AntibodyImmune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Mouse TNF-alpha/TNFA Recombinant Protein (RPES4097) |
| Product Code: | RPES4097 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | E.coli |
| Synonyms: | Tumor Necrosis Factor, Cachectin, TNF-Alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Tumor Necrosis Factor, Membrane Form, Tumor Necrosis Factor, Tnf,Tnfsf2,DIF,TNF-alpha,Tnfa,TNFalpha,Tnfsf1a,TNFSF2 |
| Accession: | NP_038721.1 |
| Sequence: | Leu 80-Leu 235 |
| Activity: | Measured in a cytotoxicity assay using L929µmouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 3-30 pg/mL. |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the soluble form of mouse TNF-? (NP_038721.1) (Leu 80-Leu 235) was expressed, with an initial Met at the C-terminus. |
| Purity: | > 98 % as determined by SDS-PAGE |
| Mol Mass: | 17 kDa |
| AP Mol Mass: | 17 kDa |
| Formulation: | Lyophilized from sterile 50mM Tris 0.2M NaCl, pH 7.2 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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