Growth Factors & Cytokines Recombinant Proteins
Mouse Thrombopoietin/TPO Recombinant Protein (RPES3187)
- SKU:
- RPES3187
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Growth Factors & Cytokines
Description
Mouse Thrombopoietin/TPO Recombinant Protein
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
| Product Name: | Mouse Thrombopoietin/TPO Recombinant Protein (RPES3187) |
| Product Code: | RPES3187 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Thrombopoietin,C-mpl ligand,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,Myeloproliferative leukemia virus oncogene ligand,THPO |
| Accession: | P40226 |
| Sequence: | Ser22Thr356 |
| Fusion tag: | N-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22-Thr356 is expressed with a 6His tag at the N-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 36.4 kDa |
| AP Mol Mass: | 80-110 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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