Mouse SLAMF6/Ly108 Recombinant Protein (RPES3225)
- SKU:
- RPES3225
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse SLAMF6/Ly108 Recombinant Protein
SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
| Product Name: | Mouse SLAMF6/Ly108 Recombinant Protein (RPES3225) |
| Product Code: | RPES3225 |
| Size: | 50µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | KAL1,KAL1b,Ly108,NTB-A,NTBA,SF2000 |
| Accession: | NP_109635.1 |
| Sequence: | Met 1-Asn 239 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse SLAMF6 (NP_109635.1) extracellular domain (Met 1-Asn 239) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 24.4 kD |
| AP Mol Mass: | 40-45 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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