Mouse Signal Regulatory Protein ? (SIRP?) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRP? can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRP? acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRP? shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRP? engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation
Product Name:
Mouse SIRPA/CD172a Recombinant Protein (RPES2971)
Product Code:
RPES2971
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, CD172 Antigen-Like Family Member A,Signal-Regulatory Protein Alpha-1, CD172a, SIRPA, MFR, SHPS1, SIRP
Accession:
Q6P6I8
Sequence:
Lys32-Asn372
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Signal-Regulatory Protein alpha 1 is produced by our Mammalian expression system and the target gene encoding Lys32-Asn372 is expressed with a Fc tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
65.1 kDa
AP Mol Mass:
115-125 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetMouse CD172a/SIRPA Recombinant Protein Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-li
system_update_altDatasheetMouse CD172a/SIRPA Recombinant Protein Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-li
system_update_altDatasheetMouse SIRPA/CD172a Recombinant Protein Mouse Signal Regulatory Protein ? (SIRP?) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one I
system_update_altDatasheetMouse SIRPA/CD172a Recombinant Protein SIRP? is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alp
system_update_altDatasheetHuman CD172a/SIRPA Recombinant Protein Signal Regulatory Protein ? (SIRP?) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human
