Enzymes Recombinant Proteins

Mouse SERPINE2 Recombinant Protein (RPPB2271)

(No reviews yet) Write a Review
SKU:
RPPB2271

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse SERPINE2 Recombinant Protein
Product Code:RPPB2271
Size:10µg
Species:Mouse
Target:SERPINE2
Synonyms:Serpnie2, B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4, Glia-derivednexin, GDN,Peptidase inhibitor 7, Protease nexin 1, Protease nexin I, Serineprotease-inhibitor 4, Serpin E2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SERPINE2 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:SQFNSLSLEE LGSNTGIQVF NQIIKSRPHE NVVVSPHGIA SILGMLQLGADGKTKKQLST VMRYNVNGVG KVLKKINKAI VSKKNKDIVT VANAVFLRNG FKMEVPFAVR NKDVFQCEVQNVNFQDPASA SESINFWVKN ETRGMIDNLL SPNLIDGALT RLVLVNAVYF KGLWKSRFQP ESTKKRTFVAGDGKSYQVPM LAQLSVFRSG STRTPNGLWY NFIELPYHGE SISMLIALPT ESSTPLSAII PHITTKTIDSWMNTMVPKRM QLVLPKFTAV AQTDLKEPLK ALGITEMFEP SKANFTKITR SESLHVSHIL QKAKIEVSEDGTKASAATTA ILIARSSPPW FIVDRPFLFS IRHNPTGAIL FLGQVNKPLE HHHHHH

PlasminogenActivator Inhibitor-2 (Serpine2) which inhibits thrombin, plasmin andplasminogen activators is a part of the Serpin superfamily of the serineprotease inhibitors. Serpine2 is able to transform human embryonic kidney cellsinto neuron-like cells. Furthermore, Serpine2's over expression in mice leadsto progressive neuronal and motor dysfunction.

SERPINE2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 386 amino acids (20-397a.a.) andhaving a molecular mass of 42.9kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).SERPINE2 is expressed with a 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Inhibitor; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; extrinsic to external side of plasma membrane; membrane; cell soma; cell; extracellular region; cytosol; neuromuscular junction; vesicle

Molecular Function:serine-type endopeptidase inhibitor activity; heparin binding; glycosaminoglycan binding; protease inhibitor activity; receptor binding

Biological Process: negative regulation of proteolysis; nervous system development; regulation of synaptic transmission, glutamatergic; secretory granule organization and biogenesis; multicellular organismal development; cerebellar granular layer morphogenesis; negative regulation of peptidase activity; negative regulation of blood coagulation; mating plug formation; detection of mechanical stimulus involved in sensory perception; negative regulation of cell proliferation; negative regulation of smoothened signaling pathway; response to wounding; negative regulation of cell growth; blood coagulation; cell differentiation; negative regulation of protein catabolic process; regulation of timing of cell differentiation; negative regulation of phosphoinositide 3-kinase cascade; positive regulation of astrocyte differentiation; secretion by cell

UniProt Code:Q07235
NCBI GenInfo Identifier:6678099
NCBI Gene ID:20720
NCBI Accession:NP_033281.1
UniProt Secondary Accession:Q07235,Q921T7,
UniProt Related Accession:Q07235
Molecular Weight:44,207 Da
NCBI Full Name:glia-derived nexin
NCBI Synonym Full Names:serine (or cysteine) peptidase inhibitor, clade E, member 2
NCBI Official Symbol:Serpine2��
NCBI Official Synonym Symbols:PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik��
NCBI Protein Information:glia-derived nexin; GDN; serpin E2; protease nexin 1; protease nexin I; peptidase inhibitor 7; serine protease inhibitor 4; serine protease-inhibitor 4; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
UniProt Protein Name:Glia-derived nexin
UniProt Synonym Protein Names:Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serine protease-inhibitor 4; Serpin E2
Protein Family:Glia-derived nexin
UniProt Gene Name:Serpine2��
UniProt Entry Name:GDN_MOUSE
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q07235
Research Area:
Enzymes
View AllClose

Related Products