Cardiovascular Recombinant Proteins

Mouse SerpinD1/HCF2 Recombinant Protein (RPES2873)

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RPES2873

Description

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Mouse SerpinD1/HCF2 Recombinant Protein

SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.

Product Name:Mouse SerpinD1/HCF2 Recombinant Protein (RPES2873)
Product Code:RPES2873
Size:10µg
Species:Mouse
Expressed Host:Human Cells
Synonyms:Heparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, Serpin D1
Accession:P49182
Sequence:Glu24-Ser478
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Mouse Serine Protease Inhibitor-clade D1 is produced by our Mammalian expression system and the target gene encoding Glu24-Ser478 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by SDS-PAGE
Mol Mass:53.1 kDa
AP Mol Mass:70-90 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Research Area:
Cardiovascular
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