Mouse SERPINA9 Recombinant Protein (RPPB4633)

Serpin Peptidase Inhibitor, Clade AMember 9, also known as serpin A9, belongs to the Serpin superfamily of serineprotease inhibitors. Serpins are the most extensively distributed superfamilyof protease inhibitors which use a conformational modification to inhibittarget enzymes. Serpins are known to inhibit serine proteases as well asinhibiting caspases in addition to papain-like cysteine proteases. Serpins areconformational labile and numerous of the disease-linked mutations of serpinsoutcome in misfolding or in pathogenic, inactive polymers. serpin A9demonstrates inhibition towards trypsin, thrombin, as well as plasmin and bindsDNA and heparin.

SERPINA9 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 401 amino acids (26-418 a.a) and having a molecular mass of 45.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).SERPINA9 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.