Mouse SERPINA6 Recombinant Protein (RPPB4631)

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RPPB4631

Description

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Product Name:Mouse SERPINA6 Recombinant Protein
Product Code:RPPB4631
Size:10µg
Species:Mouse
Target:SERPINA6
Synonyms:Corticosteroid-binding globulin, CBG, Serpin A6, Transcortin, Serpina6.
Source:HEK293 Cells
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:SERPINA6 was filtered (0.4�m) and lyophilized in phosphate buffered saline pH8.0.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. SERPINA6 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:VTDEDSSSHR DLAPTNVDFA FNLYKRLVAL NSDKNTLISP VSISMALAML SLSTRGSTQY LENLGFNMSK MSEAEIHQGF QYLNSLLQQS DTGLEMNMGN VMFLLQNLKL KDSFLADTKH YYESEALTIP SKDWTKAGEQ INNHVKNKTQ GKIEHVVSDL DSSATLILIN YIFLKGIWKL PFSPENTREE DFYVNETSTV KVPMMVQSGN ISYFRDSAIP CQMVQMNYVG NGTTFIILPD QGQMDTVVAA LNRDTIDRWG KLMIPRQMNL YIPKFSMSDT YDLQDVLADV GIKDLFTNQS DFADTTKDTP LTLTVLHKAM LQLDEGNVLP AATNGPPVHL PSESFTLKYN RPFIFLAFDK YTWSSLMMSQ VMNPA HHHHH HHHH

Serpin Peptidase Inhibitor, Clade A Member 6 (SERPINA6) is a member of the serpin superfamily. SERPINA6 is synthesized and secreted by hepatocytes in the liver and is found in glycocorticoid responsive cells. The concentration of SERPINA6 is regulated by estrogens. SERPINA6 is the main transport protein for progestins and glucocorticoids within the blood. Therefore SERPINA6 regulates their bioavailability and metabolic clearance and protects them from absorption into cells and degradation by chemicals and enzymes. SERPINA6 contains a single steroid binding site with high affinity for cortisol and progesterone. Approximately 80-90% of circulating cortisol is bound to SERPINA6. The SERPINA6 bound cortisol is considered to be biologically inactive, whereas the unbound cortisol constitutes the active form of cortisol. The active portion of plasma cortisol will therefore depend on the concentration of SERPINA6. SERPINA6 gene defects cause the corticosteroid binding globulin deficiency (CBG deficiency), a rare disorder characterized by reduced CBG production which results in hypo/ hypertension and muscle fatigue.

SERPINA6 Mouse Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Val23-Ala397) containing a total of 384 amino acids, having a calculated molecular mass of 43.5kDa and fused to a 9 aa His tag at C-Terminus.

UniProt Protein Function:Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
NCBI Summary:This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
UniProt Code:Q06770
NCBI GenInfo Identifier:6680856
NCBI Gene ID:12401
NCBI Accession:NP_031644.1
UniProt Related Accession:Q06770
Molecular Weight:
NCBI Full Name:corticosteroid-binding globulin
NCBI Synonym Full Names:serine (or cysteine) peptidase inhibitor, clade A, member 6
NCBI Official Symbol:Serpina6��
NCBI Official Synonym Symbols:Cbg��
NCBI Protein Information:corticosteroid-binding globulin
UniProt Protein Name:Corticosteroid-binding globulin
UniProt Synonym Protein Names:Serpin A6; Transcortin
UniProt Gene Name:Serpina6��
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q06770
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