Mouse Serpin F1/PEDF Recombinant Protein (RPES3563)
- SKU:
- RPES3563
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse Serpin F1/PEDF Recombinant Protein
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
| Product Name: | Mouse Serpin F1/PEDF Recombinant Protein (RPES3563) |
| Product Code: | RPES3563 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | AI195227 Protein, Mouse,EPC-1 Protein, Mouse,Pedf Protein, Mouse,Pedfl Protein, Mouse,Sdf3 Protein, Mouse |
| Accession: | NP_035470.3 |
| Sequence: | Met 1-Thr 417 |
| Fusion tag: | C-His |
| Activity: | Measured by its binding ability in a functional ELISA.Immobilized mouse SERPINF1-His at 10 µg/ml (100 ?l/well) can bind biotinylated human GST-CSNK2A1 with a linear range of 0.31-2.5 µg/ml. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Thr 417) of mouse SerpinF1 (NP_035470.3) precursor was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 45.8 kDa |
| AP Mol Mass: | 60-65 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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