Mouse S100b Recombinant Protein (RPPB4573)
- SKU:
- RPPB4573
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P50114
Description
| Product Name: | Mouse S100b Recombinant Protein |
| Product Code: | RPPB4573 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | S100b |
| Synonyms: | Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, Bpb, AI850290, MGC74317, S100b. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | S100B Mouse solution containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDEDGDGECD FQEFMAFVAM VTTACHEFFE HE |
S100B faintly binds calcium but binds zinc extremely strongly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. S100B binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction participates in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
S100B Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 92 amino acids (1-112 a.a.) and having a molecular mass of 12.8 kDa. The Mouse S100B is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family. |
| UniProt Protein Details: | Protein type:Calcium-binding Cellular Component: ruffle; extracellular space; cell soma; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus Molecular Function:identical protein binding; RAGE receptor binding; protein homodimerization activity; zinc ion binding; metal ion binding; calcium ion binding; calcium-dependent protein binding; receptor binding Biological Process: regulation of long-term neuronal synaptic plasticity; cellular calcium ion homeostasis; regulation of cell shape; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of cell proliferation; energy reserve metabolic process; positive regulation of synaptic transmission; regulation of cytokine biosynthetic process; memory; regulation of neuronal synaptic plasticity |
| UniProt Code: | P50114 |
| NCBI GenInfo Identifier: | 6677839 |
| NCBI Gene ID: | 20203 |
| NCBI Accession: | NP_033141.1 |
| UniProt Related Accession: | P50114 |
| Molecular Weight: | 10,728 Da |
| NCBI Full Name: | protein S100-B |
| NCBI Synonym Full Names: | S100 protein, beta polypeptide, neural |
| NCBI Official Symbol: | S100b�� |
| NCBI Official Synonym Symbols: | Bpb; AI850290�� |
| NCBI Protein Information: | protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B |
| UniProt Protein Name: | Protein S100-B |
| UniProt Synonym Protein Names: | S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B |
| Protein Family: | Protein |
| UniProt Gene Name: | S100b�� |
| UniProt Entry Name: | S100B_MOUSE |
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