Mouse S100A4 Recombinant Protein (RPPB4557)
- SKU:
- RPPB4557
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P07091
Description
| Product Name: | Mouse S100A4 Recombinant Protein |
| Product Code: | RPPB4557 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | S100A4 |
| Synonyms: | Protein S100-A4, S100 calcium-binding protein A4, Metastasin, Protein Mts1, Placental calcium-binding protein, Calvasculin, S100A4, CAPL, MTS1, 42A, 18A2, FSP1, P9KA, PEL98. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | S100A4 protein solution (1mg/1ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MARPLEEALD VIVSTFHKYS GKEGDKFKLN KTELKELLTR ELPSFLGKRT DEAAFQKVMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK K |
S100A4 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 may function in motility, invasion, and tubulin polymerization. There are at least 13 members in the S100 gene family, which are located as a cluster on chromosome 1q21. Chromosomal rearrangements and altered expression of the S100A4 gene have been implicated in tumor metastasis.
S100A4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 121 amino acids (1-101 a.a) and having a molecular mass of 13.9kDa.S100A4 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | S100A4: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]Protein type: Motility/polarity/chemotaxisCellular Component: extracellular space; neuron projection; perinuclear region of cytoplasm; nucleusMolecular Function: identical protein binding; RAGE receptor binding; protein binding; metal ion binding; calcium ion binding; actin binding; calcium-dependent protein bindingBiological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P07091 |
| NCBI GenInfo Identifier: | 33859624 |
| NCBI Gene ID: | 20198 |
| NCBI Accession: | NP_035441.1 |
| UniProt Secondary Accession: | P07091,P20066 |
| UniProt Related Accession: | P07091 |
| Molecular Weight: | 11,721 Da |
| NCBI Full Name: | protein S100-A4 |
| NCBI Synonym Full Names: | S100 calcium binding protein A4 |
| NCBI Official Symbol: | S100a4�� |
| NCBI Official Synonym Symbols: | 42a; 18A2; Capl; FSp1; Mts1; pk9a; PeL98; metastasin�� |
| NCBI Protein Information: | protein S100-A4; calvasculin; protein 18A2; protein Mts1; metastatic cell protein; S100 calcium-binding protein A4; placental calcium-binding protein |
| UniProt Protein Name: | Protein S100-A4 |
| UniProt Synonym Protein Names: | Metastasin; Metastatic cell protein; PEL98; Placental calcium-binding protein; Protein 18A2; Protein Mts1; S100 calcium-binding protein A4 |
| Protein Family: | Protein |
| UniProt Gene Name: | S100a4�� |
| UniProt Entry Name: | S10A4_MOUSE |
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