Mouse RSPO1 Recombinant Protein (RPPB4530)
- SKU:
- RPPB4530
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9Z132
Description
| Product Name: | Mouse RSPO1 Recombinant Protein |
| Product Code: | RPPB4530 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | RSPO1 |
| Synonyms: | R-spondin-1, Cristin-3, mCristin-3, Roof plate-specificspondin-1, Rspo1, RSPO, R-spondin 1,R-spondin, Rspondin, CRISTIN3. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RSPO1 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSRGIKGKRQRRISAEGS QACAKGCELC SEVNGCLKCS PKLFILLERN DIRQVGVCLP SCPPGYFDAR NPDMNKCIKCKIEHCEACFS HNFCTKCQEG LYLHKGRCYP ACPEGSTAAN STMECGSPAQ CEMSEWSPWG PCSKKRKLCGFRKGSEERTR RVLHAPGGDH TTCSDTKETR KCTVRRTPCP EGQKRRKGGQ GRRENANRHP ARKNSKEPGSNSRRHKGQQQ PQPGTTGPLT SVGPTWAQHH HHHH |
R-Spondin-1(Rspo1) is a part of the Rspondin family. Rspo1 plays a role as an activator ofthe canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors.Rspo1 induces the onset of crypt cell proliferation and increases intestinalepithelial healing effect. Rspo1 is negatively regulating the TGF-beta pathway.
RSPO1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 254 amino acids (21-265a.a.) andhaving a molecular mass of 28.2kDa (Molecular size on SDS-PAGE will appear atapproximately 28-40kDa).RSPO1 is expressed with an 9 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | R-spondin-1: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC). This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptide; Cell adhesion; Cell development/differentiationCellular Component: extracellular space; extracellular region; nucleusMolecular Function: heparin binding; protein binding; G-protein-coupled receptor binding; receptor bindingBiological Process: Wnt receptor signaling pathway; regulation of gene expression; regulation of receptor internalization; response to stimulus; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation; male meiosis; positive regulation of Wnt receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Z132 |
| NCBI GenInfo Identifier: | 227452351 |
| NCBI Gene ID: | 192199 |
| NCBI Accession: | NP_619624.2 |
| UniProt Secondary Accession: | Q9Z132,Q3V1S3 |
| UniProt Related Accession: | Q9Z132 |
| Molecular Weight: | 29,332 Da |
| NCBI Full Name: | R-spondin-1 |
| NCBI Synonym Full Names: | R-spondin homolog (Xenopus laevis) |
| NCBI Official Symbol: | Rspo1�� |
| NCBI Official Synonym Symbols: | Rspondin; R-spondin�� |
| NCBI Protein Information: | R-spondin-1; cristin-3; mCristin-3; roof plate-specific spondin-1; thrombospondin type 1 domain containing gene Rspondin; cysteine-rich and single thrombospondin domain-containing protein 3 |
| UniProt Protein Name: | R-spondin-1 |
| UniProt Synonym Protein Names: | Cysteine-rich and single thrombospondin domain-containing protein 3; Cristin-3; mCristin-3; Roof plate-specific spondin-1 |
| Protein Family: | R-spondin |
| UniProt Gene Name: | Rspo1�� |
| UniProt Entry Name: | RSPO1_MOUSE |
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