Mouse REN Recombinant Protein (RPPB4441)

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SKU:
RPPB4441
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P06281

Description

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Product Name:Mouse REN Recombinant Protein
Product Code:RPPB4441
Size:5µg
Species:Mouse
Target:REN
Synonyms:Renin-1, Angiotensinogenase, Kidney renin, Ren1, Ren,Ren-A, Ren1c, Ren1d, Rn-1, Rnr.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:REN protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:LPTRTATFER IPLKKMPSVR EILEERGVDM TRLSAEWGVF TKRPSLTNLTSPVVLTNYLN TQYYGEIGIG TPPQTFKVIF DTGSANLWVP STKCSRLYLA CGIHSLYESS DSSSYMENGSDFTIHYGSGR VKGFLSQDSV TVGGITVTQT FGEVTELPLI PFMLAKFDGV LGMGFPAQAV GGVTPVFDHILSQGVLKEEV FSVYYNRGSH LLGGEVVLGG SDPQHYQGNF HYVSISKTDS WQITMKGVSV GSSTLLCEEGCAVVVDTGSS FISAPTSSLK LIMQALGAKE KRIEEYVVNC SQVPTLPDIS FDLGGRAYTL SSTDYVLQYPNRRDKLCTLA LHAMDIPPPT GPVWVLGATF IRKFYTEFDR HNNRIGFALA RHHHHHH

Renin is a highly specific endopeptidase which generates angiotensin I from angiotensinogen in the plasma. angiotensin I is an important regulator of blood pressure and electrolyte balance. Renin initiates a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

REN produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 387 amino acids (22-402 a.a.) andhaving a molecular mass of 42.5kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).REN is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; EC 3.4.23.15; Protease; Secreted, signal peptide

Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; intracellular

Molecular Function:peptidase activity; insulin-like growth factor receptor binding; hydrolase activity; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to drug; response to cAMP; establishment of blood-nerve barrier; hormone-mediated signaling; cell maturation; renin-angiotensin regulation of aldosterone production; drinking behavior; angiotensin maturation; proteolysis; response to organic substance; regulation of MAPKKK cascade; regulation of blood pressure; renin-angiotensin regulation of blood volume; kidney development

UniProt Code:P06281
NCBI GenInfo Identifier:132327
NCBI Gene ID:19701
NCBI Accession:P06281.1
UniProt Secondary Accession:P06281,P97911, Q543E5, Q62153, Q62154,
UniProt Related Accession:P06281
Molecular Weight:44,343 Da
NCBI Full Name:Renin-1
NCBI Synonym Full Names:renin 1 structural
NCBI Official Symbol:Ren1��
NCBI Official Synonym Symbols:Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352��
NCBI Protein Information:renin-1; renin b; kidney renin; aspartyl-protease; angiotensinogenase
UniProt Protein Name:Renin-1
UniProt Synonym Protein Names:Angiotensinogenase; Kidney renin
Protein Family:Renin
UniProt Gene Name:Ren1��
UniProt Entry Name:RENI1_MOUSE
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