Mouse RAPSN Recombinant Protein (RPPB4405)

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SKU:
RPPB4405
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P12672

Description

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Product Name:Mouse RAPSN Recombinant Protein
Product Code:RPPB4405
Size:20µg
Species:Mouse
Target:RAPSN
Synonyms:Receptor-Associated Protein Of The Synapse, 43 KDaPostsynaptic Protein, Acetylcholine Receptor-Associated 43 KDa Protein, RNF205,RING Finger Protein 205, rapsyn, Receptor-Associated Protein Of The Synapse,43Kd, 43 KDa Receptor-Associated Protein Of The Synapse, RAPSYN, RAPsyn, CMS1D,CMS1E.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:RAPSN protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGQDQTK QQIEKGLQLY QSNQTEKALQ VWMKVLEKGS DLVGRFRVLGCLVTAHSEMG RYKEMLKFAV VQIDTARGLE DADFLLESYL NLARSNEKLC EFHKTISYCK TCLGLPGTRAGAQLGGQVSL SMGNAFLGLS LFQKALESFE KALRYAHNND DTMLECRVCC SLGSFYAQVK DYEKALFFPC KAAELVNDYG KGWSLKYRAMSQYHMAVAYR LLGHLGSAME CCEESMKIAL QHGDRPLQAL CLLCFADIHR SRGDLETAFP RYDSAMSIMTEIGNRLGQVH VLLGVAKCWM ARKVQDKALD AIEKAQDLAE EVGNKLSQLK LHCLSESIYR SKGLQRELRT HVVRFHECVE ETELYCGLCG ESIGERNSRL QALPCSHIFHLRCLQNNGTR SCPNCRRSSM KPGFV
UniProt Code:P12672

43kDa receptor-associated protein of the synapse (RAPSN), is expressed in the postsynapticmembrane of skeletal muscle. RAPSN is essential for the clustering of nicotinicacetylcholine receptors (nAChR). In addition RAPSN self-associates via at leasttwo of its seven tetra-tricopeptide repeats (TPRs). RAPSN interacts withthe large intracellular domain of the nAChR a subunit all the way through thehydrophobic surface of the coiled-coil domain.RAPSN modifies trafficking of AChR within the cell. Overexpressioninhibits agrin-induced AChR clustering pathway. RAPSN also plays a role inpostsynaptic congenital myasthenic syndromes.

RAPSN Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 435 amino acids (1-412aa) and having a molecular mass of 48.8kDa.RAPSN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

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