Mouse RANK/TNFRSF11A Recombinant Protein (RPES2691)
- SKU:
- RPES2691
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse RANK/TNFRSF11A Recombinant Protein
Receptor activator of NF-?B(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, brain and kidney, but weakly expressed in spleen and bone marrow. After binding its ligand RANKL, RANK can activate signaling pathways such as NF-?B, JNK, ERK, p38, and Akt/PKB, through TRAF protein phosphorylation. RANK/TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK/TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.
| Product Name: | Mouse RANK/TNFRSF11A Recombinant Protein (RPES2691) |
| Product Code: | RPES2691 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Receptor activator of NF-KB, tumor necrosis factor receptor superfamily member 11A, TRANCE receptor, Osteoclast differentiation factor receptor,NFKB activator, TRANCER, CD265, TNFRSF11A, TRANCE R, CD265 antigen, ODFR |
| Accession: | O35305 |
| Sequence: | Val31-Ser214 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Receptor Activator of NF-kappa B is produced by our Mammalian expression system and the target gene encoding Val31-Ser214 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 21.3 kDa |
| AP Mol Mass: | 26-30 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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