Hormones Recombinant Proteins

Mouse Procalcitonin Recombinant Protein (RPPB1290)

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RPPB1290

Description

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Product Name:Mouse Procalcitonin Recombinant Protein
Product Code:RPPB1290
Size:10µg
Species:Mouse
Target:Procalcitonin
Synonyms:Calcitonin, Calca, Calc.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:Procalcitonin was filtered (0.4 �m) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Procalcitonin is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 94.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASVPLRSILESS PGMATLSEEE VRLLAALVQD YMQMKARELE QEEEQEAEGS SLDSPRSKRC GNLSTCMLGT YTQDLNKFHT FPQTSIGVEA PGKKRDVAKD LETNHQSHFG N

Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.

Procalcitonin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val26-Ser136) containing 121 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 13.6kDa.

UniProt Protein Function:CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7 F1|7 59.99 cM

Cellular Component: axon; cell soma; cytoplasm; extracellular region; extracellular space; intracellular; neuron projection; nucleus; terminal button

Molecular Function:calcitonin receptor binding; receptor binding

Biological Process: adenylate cyclase activation; cellular calcium ion homeostasis; detection of temperature stimulus involved in sensory perception of pain; feeding behavior; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; negative regulation of blood pressure; negative regulation of neurological process; negative regulation of ossification; negative regulation of smooth muscle contraction; neuromuscular junction development; neuropeptide signaling pathway; positive regulation of cell adhesion; positive regulation of ossification; regulation of blood pressure; regulation of heart contraction; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; sperm capacitation; vasodilation; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure

NCBI Summary:This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]
UniProt Code:P70160
NCBI GenInfo Identifier:2493431
NCBI Gene ID:12310
NCBI Accession:P70160.1
UniProt Secondary Accession:P70160,Q8K1K5,
UniProt Related Accession:P70160,Q99JA0
Molecular Weight:14.7kDa
NCBI Full Name:Calcitonin
NCBI Synonym Full Names:calcitonin/calcitonin-related polypeptide, alpha
NCBI Official Symbol:Calca��
NCBI Official Synonym Symbols:CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1��
NCBI Protein Information:calcitonin gene-related peptide 1
UniProt Protein Name:Calcitonin
UniProt Gene Name:Calca��
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P70160
Research Area:
Hormones
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