Enzymes Recombinant Proteins

Mouse PKM2 Recombinant Protein (RPPB2622)

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SKU:
RPPB2622
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P52480
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse PKM2 Recombinant Protein
Product Code:RPPB2622
Size:10µg
Species:Mouse
Target:PKM2
Synonyms:Pyruvate kinase isozymes M1/M2, EC 2.7.1.40, Pyruvate kinase muscle isozyme, Pyruvate kinase 2/3, Cytosolic thyroid hormone-binding protein, CTHBP, THBP1, M2PK, PKM2, PK3, PK2, PKM, TCB, OIP3, MGC3932, Tumor Type M2 Pyruvate Kinase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PKM2 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH 8.5), 0.2M NaCl, 1mM DTT and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPKPHSE AGTAFIQTQQ LHAAMADTFL EHMCRLDIDS APITARNTGI ICTIGPASRS VEMLKEMIKS GMNVARLNFS HGTHEYHAET IKNVREATES FASDPILYRP VAVALDTKGP EIRTGLIKGS GTAEVELKKG ATLKITLDNA YMEKCDENIL WLDYKNICKV VEVGSKIYVD DGLISLQVKE KGADFLVTEV ENGGSLGSKK GVNLPGAAVD LPAVSEKDIQ DLKFGVEQDV DMVFASFIRK AADVHEVRKV LGEKGKNIKI ISKIENHEGV RRFDEILEAS DGIMVARGDL GIEIPAEKVF LAQKMMIGRC NRAGKPVICA TQMLESMIKK PRPTRAEGSD VANAVLDGAD CIMLSGETAK GDYPLEAVRM QHLIAREAEA AIYHLQLFEE LRRLAPITSD PTEAAAVGAV EASFKCCSGA IIVLTKSGRS AHQVARYRPR APIIAVTRNP QTARQAHLYR GIFPVLCKDA VLNAWAEDVD LRVNLAMDVG KARGFFKKGD VVIVLTGWRP GSGFTNTMRV VPVP
Biological Activity:Specific activity: > 500 units/mg. One unit will convert 1 pmole of phospho(enol)pyruvate to pyruvate per minute at pH 7.5 at 37�C.

Pyruvate kinase is a key enzyme in the glycolytic pathway. The M2 isoenzyme of pyruvate kinase is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. The marker is useful for measuring disease activity, sensitivity to chemotherapy and recurrence.

PKM2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 554 amino acids (1-531 a.a) and having a molecular mass of 60.2kDa. PKM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation.
UniProt Code:P52480
NCBI GenInfo Identifier:146345448
NCBI Gene ID:18746
NCBI Accession:P52480.4
UniProt Secondary Accession:P52480,Q3TBV8, Q3TBW5, Q3TC59, Q3U1X3, Q3U5P6, Q4VC20 Q64484, Q91YI8, Q9CWB1,
UniProt Related Accession:P52480
Molecular Weight:57,985 Da
NCBI Full Name:Pyruvate kinase PKM
NCBI Synonym Full Names:pyruvate kinase, muscle
NCBI Official Symbol:Pkm��
NCBI Official Synonym Symbols:Pk3; Pk-2; Pk-3; Pkm2; AA414905; AL024370; AL024424��
NCBI Protein Information:pyruvate kinase PKM
UniProt Protein Name:Pyruvate kinase PKM
UniProt Synonym Protein Names:Pyruvate kinase muscle isozyme
UniProt Gene Name:Pkm��
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