Growth Factors & Cytokines Recombinant Proteins

Mouse PGF1 Recombinant Protein (RPPB0863)

(No reviews yet) Write a Review
SKU:
RPPB0863

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse PGF1 Recombinant Protein
Product Code:RPPB0863
Size:10µg
Species:Mouse
Target:PGF1
Synonyms:Placenta growth factor, PlGF, PGF1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:PGF1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4), 0.1mM PMSF and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:AGNNSTEVEV VPFNEVWGRS YCRPMEKLVY ILDEYPDEVS HIFSPSCVLLSRCSGCCGDE GLHCVPIKTA NITMQILKIP PNRDPHFYVE MTFSQDVLCE CRPILETTKA ERRKTKGKRKRSRNSQTEEP HPHHHHHH

Placental Growth Factor, also known asPGF is rich in trophoblastic giant cells which are linked with the parietal yolk sac at early stages ofembryogenesis. Furthermore, the secretion of PGF by trophoblastic giant cellsis the signal which initiates as well as co-ordinates vascularization in thedeciduum and placenta during early embryogenesis.

PGF1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 138 amino acids (27-158a.a.) and having a molecular mass of 15.9kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). PGF1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space; membrane

Molecular Function:growth factor activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: angiogenesis; cell differentiation; multicellular organismal development; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; sprouting angiogenesis; ureteric bud branching

UniProt Code:P49764
NCBI GenInfo Identifier:6679289
NCBI Gene ID:18654
NCBI Accession:NP_032853.1
UniProt Related Accession:P49764
Molecular Weight:17,876 Da
NCBI Full Name:placenta growth factor isoform 1
NCBI Synonym Full Names:placental growth factor
NCBI Official Symbol:Pgf��
NCBI Official Synonym Symbols:PIGF; Plgf; AI854365��
NCBI Protein Information:placenta growth factor
UniProt Protein Name:Placenta growth factor
Protein Family:Placenta growth factor
UniProt Gene Name:Pgf��
UniProt Entry Name:PLGF_MOUSE
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P49764
Research Area:
Growth Factors & Cytokines
View AllClose

Related Products