Growth Factors & Cytokines Recombinant Proteins
Mouse PGF1 Recombinant Protein (RPPB0863)
- SKU:
- RPPB0863
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P49764
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse PGF1 Recombinant Protein |
| Product Code: | RPPB0863 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PGF1 |
| Synonyms: | Placenta growth factor, PlGF, PGF1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PGF1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4), 0.1mM PMSF and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AGNNSTEVEV VPFNEVWGRS YCRPMEKLVY ILDEYPDEVS HIFSPSCVLLSRCSGCCGDE GLHCVPIKTA NITMQILKIP PNRDPHFYVE MTFSQDVLCE CRPILETTKA ERRKTKGKRKRSRNSQTEEP HPHHHHHH |
Placental Growth Factor, also known asPGF is rich in trophoblastic giant cells which are linked with the parietal yolk sac at early stages ofembryogenesis. Furthermore, the secretion of PGF by trophoblastic giant cellsis the signal which initiates as well as co-ordinates vascularization in thedeciduum and placenta during early embryogenesis.
PGF1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 138 amino acids (27-158a.a.) and having a molecular mass of 15.9kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). PGF1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular region; extracellular space; membrane Molecular Function:growth factor activity; protein heterodimerization activity; protein homodimerization activity Biological Process: angiogenesis; cell differentiation; multicellular organismal development; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; sprouting angiogenesis; ureteric bud branching |
| UniProt Code: | P49764 |
| NCBI GenInfo Identifier: | 6679289 |
| NCBI Gene ID: | 18654 |
| NCBI Accession: | NP_032853.1 |
| UniProt Related Accession: | P49764 |
| Molecular Weight: | 17,876 Da |
| NCBI Full Name: | placenta growth factor isoform 1 |
| NCBI Synonym Full Names: | placental growth factor |
| NCBI Official Symbol: | Pgf�� |
| NCBI Official Synonym Symbols: | PIGF; Plgf; AI854365�� |
| NCBI Protein Information: | placenta growth factor |
| UniProt Protein Name: | Placenta growth factor |
| Protein Family: | Placenta growth factor |
| UniProt Gene Name: | Pgf�� |
| UniProt Entry Name: | PLGF_MOUSE |
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