Chemokines Recombinant Proteins
Mouse PF 4 Recombinant Protein (RPPB1238)
- SKU:
- RPPB1238
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9Z126
- Research Area:
- Chemokines
Description
| Product Name: | Mouse PF 4 Recombinant Protein |
| Product Code: | RPPB1238 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | PF 4 |
| Synonyms: | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered white lyophilized powder. |
| Formulation: | The Mouse CXCL4 protein was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, pH 7.4 and 1.0M NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized CXCL4 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL4 Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CXCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES |
| Biological Activity: | Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100ng/ml. |
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets. Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily.�
CXCL4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.2kDa.
| UniProt Protein Function: | PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Chemokine; Secreted; Apoptosis; Secreted, signal peptide; Motility/polarity/chemotaxis Cellular Component: extracellular space; protein complex; extracellular region; vesicle Molecular Function:heparin binding; CXCR3 chemokine receptor binding; chemokine activity; CXCR chemokine receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; platelet activation; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; chemotaxis; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of MHC class II biosynthetic process; protein complex assembly; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of macrophage differentiation |
| UniProt Code: | Q9Z126 |
| NCBI GenInfo Identifier: | 24638135 |
| NCBI Gene ID: | 56744 |
| NCBI Accession: | Q9Z126.1 |
| UniProt Related Accession: | Q9Z126 |
| Molecular Weight: | 11,243 Da |
| NCBI Full Name: | Platelet factor 4 |
| NCBI Synonym Full Names: | platelet factor 4 |
| NCBI Official Symbol: | Pf4�� |
| NCBI Official Synonym Symbols: | Cxcl4; Scyb4�� |
| NCBI Protein Information: | platelet factor 4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| UniProt Protein Name: | Platelet factor 4 |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 4 |
| UniProt Gene Name: | Pf4�� |
| UniProt Entry Name: | PLF4_MOUSE |
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