Chemokines Recombinant Proteins

Mouse PF 4 Recombinant Protein (RPPB1238)

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SKU:
RPPB1238
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9Z126
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse PF 4 Recombinant Protein
Product Code:RPPB1238
Size:20µg
Species:Mouse
Target:PF 4
Synonyms:CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered white lyophilized powder.
Formulation:The Mouse CXCL4 protein was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, pH 7.4 and 1.0M NaCl.
Solubility:It is recommended to reconstitute the lyophilized CXCL4 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized CXCL4 Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CXCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES
Biological Activity:Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100ng/ml.

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets. Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily.�

CXCL4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.2kDa.

UniProt Protein Function:PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Chemokine; Secreted; Apoptosis; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; protein complex; extracellular region; vesicle

Molecular Function:heparin binding; CXCR3 chemokine receptor binding; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; platelet activation; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; chemotaxis; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of MHC class II biosynthetic process; protein complex assembly; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of macrophage differentiation

UniProt Code:Q9Z126
NCBI GenInfo Identifier:24638135
NCBI Gene ID:56744
NCBI Accession:Q9Z126.1
UniProt Related Accession:Q9Z126
Molecular Weight:11,243 Da
NCBI Full Name:Platelet factor 4
NCBI Synonym Full Names:platelet factor 4
NCBI Official Symbol:Pf4��
NCBI Official Synonym Symbols:Cxcl4; Scyb4��
NCBI Protein Information:platelet factor 4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
UniProt Protein Name:Platelet factor 4
UniProt Synonym Protein Names:C-X-C motif chemokine 4
UniProt Gene Name:Pf4��
UniProt Entry Name:PLF4_MOUSE
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