Metabolism Recombinant Proteins
Mouse PDK4 Recombinant Protein (RPES0513)
- SKU:
- RPES0513
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Research Area:
- Metabolism
Description
Mouse PDK4 Recombinant Protein
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.
| Product Name: | Mouse PDK4 Recombinant Protein (RPES0513) |
| Product Code: | RPES0513 |
| Size: | 20µg |
| Species: | Mouse |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | AV005916 |
| Accession: | O70571 |
| Sequence: | Met1-Val412 |
| Fusion tag: | N-His-GST |
| Activity: | Kinase activity untested |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse PDK4 (O70571) (Met1-Val412) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 85 % as determined by SDS-PAGE |
| Mol Mass: | 74.4 kDa |
| AP Mol Mass: | 65 kDa |
| Formulation: | Supplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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