Enzymes Recombinant Proteins
Mouse PDIA3 Recombinant Protein (RPPB2084)
- SKU:
- RPPB2084
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P27773
- Research Area:
- Enzymes
Description
| Product Name: | Mouse PDIA3 Recombinant Protein |
| Product Code: | RPPB2084 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PDIA3 |
| Synonyms: | ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC, ER60, Protein disulfide-isomerase A3, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 60, ER protein 60, 58 kDa microsomal protein, Endoplasmic reticulum resident protein 57, ER protein 57, 58 kDa glucose-regulated protein, PDIA3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colourless solution. |
| Formulation: | PDIA3 protein solution (1mg/ml) containing 20 mM Tris-HCl buffer (pH8.0), 1mM DTT, 0.1M NaCl and 10% glycerol .� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSDVLEL TDENFESRVS DTGSAGLMLV EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASVVGFF RDLFSDGHSE FLKAASNLRD NYRFAHTNIE SLVKEYDDNG EGITIFRPLH LANKFEDKTV AYTEKKMTSG KIKKFIQDSI FGLCPHMTED NKDLIQGKDL LTAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA VASRKTFSHE LSDFGLESTT GEVPVVAIRT AKGEKFVMQE EFSRDGKALE QFLQEYFDGN LKRYLKSEPI PESNEGPVKV VVAENFDDIV NEEDKDVLIE FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVKGF PTIYFSPANK KLTPKKYEGG RELNDFISYL QREATNPPII QEEKPKKKKK AQEDL |
| Biological Activity: | Specific activity is >15 A650/cm/min/mg,obtained by measuring the increase of insulin precipitation in absorbance at 650nm resulting from the reduction of insulin. |
PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. PDIA3 has protein disulfide isomerase activity. Complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. PDIA3 is expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. PDIA3 interacts with thiazide-sensitive sodium-chloride cotransporter in the kidney and is induced by glucose deprivation. PDIA3 is part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is important for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.
PDIA3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 505 amino acids (25-505 a.a) and having a molecular mass of 56.8kDa.PDIA3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.�
| UniProt Code: | P27773 |
| NCBI GenInfo Identifier: | 146345480 |
| NCBI Gene ID: | 14827 |
| NCBI Accession: | P27773.2 |
| UniProt Secondary Accession: | P27773,Q3TEI9, Q3TIL2, Q3UZK8, Q8C2F4, Q99LF6, |
| UniProt Related Accession: | P27773 |
| Molecular Weight: | 56,678 Da |
| NCBI Full Name: | Protein disulfide-isomerase A3 |
| NCBI Synonym Full Names: | protein disulfide isomerase associated 3 |
| NCBI Official Symbol: | Pdia3�� |
| NCBI Official Synonym Symbols: | Erp; PDI; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]�� |
| NCBI Protein Information: | protein disulfide-isomerase A3 |
| UniProt Protein Name: | Protein disulfide-isomerase A3 |
| UniProt Synonym Protein Names: | 58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60 |
| UniProt Gene Name: | Pdia3�� |
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