Mouse PDGFRa/CD140a Recombinant Protein (RPES2526)

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SKU:
RPES2526
Product Type:
Recombinant Protein
Species:
Mouse

Description

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Mouse PDGFRa/CD140a Recombinant Protein

Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-? and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -??, -ββ and -?β. PDGFR? and PDGFRβ are members of the class III RTK family. Inappropriate PDGFR? and PDGFRβ signaling has been linked to a number of proliferative disorders.

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