Growth Factors & Cytokines Recombinant Proteins

Mouse OPG Recombinant Protein (RPPB0821)

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SKU:
RPPB0821
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
O08712
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Mouse OPG Recombinant Protein
Product Code:RPPB0821
Size:10µg
Species:Mouse
Target:OPG
Synonyms:Tumor necrosis factor receptor superfamily member 11B, Ocif, Opg, Tnfrsf11b, Osteoclastogenesis inhibitory factor, TR1.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:OPG protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ETLPPKYLHY DPETGHQLLC DKCAPGTYLK QHCTVRRKTL CVPCPDHSYT DSWHTSDECV YCSPVCKELQ SVKQECNRTH NRVCECEEGR YLEIEFCLKH RSCPPGSGVV QAGTPERNTV CKKCPDGFFS GETSSKAPCI KHTNCSTFGL LLIQKGNATH DNVCSGNREA TQKCGIDVTL CEEAFFRFAV PTKIIPNWLS VLVDSLPGTK VNAESVERIK RRHSSQEQTF QLLKLWKHQN RDQEMVKKII QDIDLCESSV QRHLGHSNLT TEQLLALMES LPGKKISPEE IERTRKTCKS SEQLLKLLSL WRIKNGDQDT LKGLMYALKH LKTSHFPKTV THSLRKTMRF LHSFTMYRLY QKLFLEMIGN QVQSVKISCL LEHHHHHH

Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.

OPG Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 388 amino acids (22-401a.a.) and having a molecular mass of 44.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).OPG is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF11B: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal.
UniProt Protein Details:

Protein type:Secreted; Inhibitor; Secreted, signal peptide

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Biological Process: extracellular matrix organization and biogenesis; apoptosis; negative regulation of odontogenesis of dentine-containing teeth; negative regulation of bone resorption; signal transduction

UniProt Code:O08712
NCBI GenInfo Identifier:21264085
NCBI Gene ID:18383
NCBI Accession:O08712.1
UniProt Secondary Accession:O08712,O70202,
UniProt Related Accession:O08712
Molecular Weight:45,923 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 11B
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
NCBI Official Symbol:Tnfrsf11b��
NCBI Official Synonym Symbols:Opg; TR1; OCIF��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 11B
UniProt Synonym Protein Names:Osteoclastogenesis inhibitory factor; Osteoprotegerin
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:Tnfrsf11b��
UniProt Entry Name:TR11B_MOUSE
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