Enzymes Recombinant Proteins
Mouse OGG1 Recombinant Protein (RPPB2057)
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- SKU:
- RPPB2057
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- O08760
- Research Area:
- Enzymes
Description
| Product Name: | Mouse OGG1 Recombinant Protein |
| Product Code: | RPPB2057 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | OGG1 |
| Synonyms: | HMMH, HOGG1, MUTM, OGH1, AP lyase, OGG1, 8-Oxoguanine DNA Glycosylase, OGG1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colourless solution. |
| Formulation: | OGG1 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH7.4) and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMLFRSWL PSSMRHRTLS SSPALWASIP CPRSELRLDL VLASGQSFRW KEQSPAHWSG VLADQVWTLT QTEDQLYCTV YRGDDSQVSR PTLEELETLH KYFQLDVSLA QLYSHWASVD SHFQRVAQKF QGVRLLRQDP TECLFSFICS SNNNIARITG MVERLCQAFG PRLIQLDDVT YHGFPNLHAL AGPEAETHLR KLGLGYRARY VRASAKAILE EQGGPAWLQQ LRVAPYEEAH KALCTLPGVG AKVADCICLM ALDKPQAVPV DVHVWQIAHR DYGWHPKTSQ AKGPSPLANK ELGNFFRNLW GPYAGWAQAV LFSADLRQPS LSREPPAKRK KGSKRPEG |
OGG1 is a DNA glycosylase enzyme which takes part in base excision repair. OGG1 protein is the main enzyme accountable for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which arises as a result of exposure to reactive oxygen species (ROS). OGG1 shows beta lyase activity that nicks DNA 3 to the lesion.
OGG1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 368 amino acids (1-345 a.a) and having a molecular mass of 41.3kDa. OGG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.�
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O08760 |
| NCBI GenInfo Identifier: | 12643533 |
| NCBI Gene ID: | 18294 |
| NCBI Accession: | O08760.2 |
| UniProt Secondary Accession: | O08760,O08733, O08910, O08991, O35617, O35915, Q9QXE8 |
| UniProt Related Accession: | O08760 |
| Molecular Weight: | 38,883 Da |
| NCBI Full Name: | N-glycosylase/DNA lyase |
| NCBI Synonym Full Names: | 8-oxoguanine DNA-glycosylase 1 |
| NCBI Official Symbol: | Ogg1�� |
| NCBI Official Synonym Symbols: | Mmh�� |
| NCBI Protein Information: | N-glycosylase/DNA lyase |
| UniProt Protein Name: | N-glycosylase/DNA lyase |
| UniProt Synonym Protein Names: | |
| Protein Family: | N-glycosylase/DNA lyase |
| UniProt Gene Name: | Ogg1�� |
| UniProt Entry Name: |
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