Enzymes Recombinant Proteins

Mouse NNMT Recombinant Protein (RPPB2032)

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RPPB2032

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse NNMT Recombinant Protein
Product Code:RPPB2032
Size:10µg
Species:Mouse
Target:NNMT
Synonyms:Nicotinamide N-methyltransferase , Nnmt, icotinamide N-methyltransferase isoform1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:NNMT protein solution (1mg/ml) containing 20mM Tris-HCl (pH8.0), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMESGFT SKDTYLSHFN PRDYLEKYYS FGSRHCAENE ILRHLLKNLF KIFCLGAVKG ELLIDIGSGP TIYQLLSACE SFTEIIVSDY TDQNLWELQK WLKKEPGAFD WSPVVTYVCD LEGNRMKGPE KEEKLRRAIK QVLKCDVTQS QPLGGVSLPP ADCLLSTLCL DAACPDLPAY RTALRNLGSL LKPGGFLVMV DALKSSYYMI GEQKFSSLPL GWETVRDAVE EAGYTIEQFE VISQNYSSTT SNNEGLFSLV GRKPGRSE

NNMT is part of the family of transferases, especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.

NNMT Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-264a.a) and having a molecular mass of 32.1kDa.NNMT is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
UniProt Protein Details:
NCBI Summary:
UniProt Code:O55239
NCBI GenInfo Identifier:8928254
NCBI Gene ID:18113
NCBI Accession:O55239.1
UniProt Secondary Accession:O55239
UniProt Related Accession:O55239
Molecular Weight:29,598 Da
NCBI Full Name:Nicotinamide N-methyltransferase
NCBI Synonym Full Names:nicotinamide N-methyltransferase
NCBI Official Symbol:Nnmt��
NCBI Official Synonym Symbols:
NCBI Protein Information:nicotinamide N-methyltransferase
UniProt Protein Name:Nicotinamide N-methyltransferase
UniProt Synonym Protein Names:
Protein Family:Nicotinamide N-methyltransferase
UniProt Gene Name:Nnmt��
UniProt Entry Name:
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
O55239
Research Area:
Enzymes
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