Chemokines Recombinant Proteins

Mouse MIP 1b Recombinant Protein (RPPB1218)

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SKU:
RPPB1218
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P14097
Research Area:
Chemokines

Description

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Product Name:Mouse MIP 1b Recombinant Protein
Product Code:RPPB1218
Size:10µg
Species:Mouse
Target:MIP 1b
Synonyms:Small inducible cytokine A4, CCL4, Macrophage inflammatory protein 1-beta, MIP-1- beta, MIP-1-beta(1-69), T-cell activation protein 2, ACT-2, PAT 744, H400, SIS-gamma, Lymphocyte activation gene 1 protein, LAG-1, HC21, G-26 T-lymphocyte-secreted protein, chemokine (C-C motif) ligand 4, ACT2, G-26, LAG1, MIP1B, SCYA2, SCYA4, AT744.1, MGC104418, MGC126025, MGC126026.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1 mg/ml) solution in water containing no additives.
Solubility:It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Mouse MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA
Biological Activity:Mouse MIP-1 beta activity is calculated by the ability to chemoattract Human blood monocytes at 20-100ng/ml corresponding to a Specific Activity of 10,000-50,000IU/mg.

Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines.

Macrophage Inflammatory Protein-1 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7808 Dalton. The MIP-1b is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function:identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: leukocyte chemotaxis; response to toxin; immune response; positive regulation of calcium-mediated signaling; positive regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of calcium ion transport; positive regulation of vascular permeability

UniProt Code:P14097
NCBI GenInfo Identifier:1346534
NCBI Gene ID:20303
NCBI Accession:P14097.3
UniProt Related Accession:P14097
Molecular Weight:10,168 Da
NCBI Full Name:C-C motif chemokine 4
NCBI Synonym Full Names:chemokine (C-C motif) ligand 4
NCBI Official Symbol:Ccl4��
NCBI Official Synonym Symbols:Act-2; Mip1b; Scya4; MIP-1B; AT744.1��
NCBI Protein Information:C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1 beta; MIP-1-beta; immune activation protein 2; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta
UniProt Protein Name:C-C motif chemokine 4
UniProt Synonym Protein Names:Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4
Protein Family:C-C motif chemokine
UniProt Gene Name:Ccl4��
UniProt Entry Name:CCL4_MOUSE
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