Chemokines Recombinant Proteins

Mouse MIP-1 Gamma Recombinant Protein (RPPB1220)

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SKU:
RPPB1220
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P51670
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse MIP-1 Gamma Recombinant Protein
Product Code:RPPB1220
Size:20µg
Species:Mouse
Target:MIP-1 Gamma
Synonyms:CCL9/10, MRP2, CCF18.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The MIP-1 gamma was lyophilized from 1xPBS solution pH-7.4.
Solubility:It is recommended to reconstitute the lyophilized MIP-1 gamma in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MIP-1 gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL9/10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:QITHATETKE VQSSLKAQQG LEIEMFHMGF QDSSDCCLSY NSRIQCSRFI GYFPTSGGCT RPGIIFISKR GFQVCANPSD RRVQRCIERL EQNSQPRTYK Q
Biological Activity:Defined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10 ng/ml, corresponding to a Specific Activity of 10,000-100,000IU/mg.

Mouse MIP-1 gamma is 75% identical in its amino acid compostion as compared to the rat specie. MIP-1 gamma is a CC chemokine localized in murine blood and a widespread range of murine tissues, without having an identified human homolog. MIP-1 gamma signals through the CCR1 receptor. MIP-1 gamma chemoattracts neutrophils and also inhibits colony formation of bone marrow myeloid immature progenitors. MIP-1 gamma has six cysteines including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 gamma Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 101 amino acids and having a molecular mass of 11.6 kDa. The MIP-1 gamma is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL9: Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitorsProtein type: CytokineCellular Component: extracellular space; extracellular regionMolecular Function: chemokine activity; cytokine activityBiological Process: immune response; negative regulation of myoblast differentiation; chemotaxis
UniProt Protein Details:
NCBI Summary:
UniProt Code:P51670
NCBI GenInfo Identifier:1709026
NCBI Gene ID:20308
NCBI Accession:P51670.1
UniProt Secondary Accession:P51670,Q5QNW2
UniProt Related Accession:P51670
Molecular Weight:13,871 Da
NCBI Full Name:C-C motif chemokine 9
NCBI Synonym Full Names:chemokine (C-C motif) ligand 9
NCBI Official Symbol:Ccl9��
NCBI Official Synonym Symbols:CCF18; MRP-2; Scya9; Scya10��
NCBI Protein Information:C-C motif chemokine 9; MIP-1 gamma; small inducible cytokine A9; small inducible cytokine A10; macrophage inflammatory protein 1-gamma; macrophage inflammatory protein-related protein 2
UniProt Protein Name:C-C motif chemokine 9
UniProt Synonym Protein Names:CCF18; Macrophage inflammatory protein 1-gamma; MIP-1-gamma; Macrophage inflammatory protein-related protein 2; MRP-2; Small-inducible cytokine A9Cleaved into the following 3 chains:CCL9(29-101); CCL9(30-101); CCL9(31-101)
Protein Family:C-C motif chemokine
UniProt Gene Name:Ccl9��
UniProt Entry Name:CCL9_MOUSE
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