Growth Factors & Cytokines Recombinant Proteins

Mouse MIF Recombinant Protein (RPPB0765)

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SKU:
RPPB0765
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P34884
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse MIF Recombinant Protein
Product Code:RPPB0765
Size:20µg
Species:Mouse
Target:MIF
Synonyms:Macrophage migration inhibitory factor, MIF, Delayedearly response protein 6, DER6, Glycosylation-inhibiting factor, GIF,L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MIF protein solution (0.5mg/ml) containing Phosphatebuffered saline , 10% glyceroland 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMPMFIVNTNVPRASVPE GFLSELTQQL AQATGKPAQY IAVHVVPDQL MTFSGTNDPC ALCSLHSIGK IGGAQNRNYSKLLCGLLSDR LHISPDRVYI NYYDMNAANV GWNGSTFA

The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.

MIF Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 138 amino acids (1-115 a.a) andhaving a molecular mass of 14.9kDa.MIF is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
UniProt Protein Details:

Catalytic activity: Keto-phenylpyruvate = enol-phenylpyruvate.1 PublicationManual assertion based on experiment in:Ref.12

UniProt Code:P34884
NCBI GenInfo Identifier:6754696
NCBI Gene ID:17319
NCBI Accession:NP_034928.1
UniProt Related Accession:P34884
Molecular Weight:12,504 Da
NCBI Full Name:macrophage migration inhibitory factor
NCBI Synonym Full Names:macrophage migration inhibitory factor
NCBI Official Symbol:Mif��
NCBI Official Synonym Symbols:GIF; Glif��
NCBI Protein Information:macrophage migration inhibitory factor; DER6; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase; glycosylation-inhibiting factor; delayed early response protein 6
UniProt Protein Name:Macrophage migration inhibitory factor
UniProt Synonym Protein Names:Delayed early response protein 6; DER6; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase (EC:5.3.3.12); Phenylpyruvate tautomerase
Protein Family:Macrophage migration inhibitory factor
UniProt Gene Name:Mif��
UniProt Entry Name:MIF_MOUSE
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system_update_altDatasheetMouse MIF Recombinant Protein Macrophage migration inhibitory factor(MIF) is a secreted protein and belongs to the MIF family. MIF is an important regulator of innate im