Growth Factors & Cytokines Recombinant Proteins
Mouse MIF Recombinant Protein (RPPB0764)
- SKU:
- RPPB0764
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P34884
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse MIF Recombinant Protein |
| Product Code: | RPPB0764 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | MIF |
| Synonyms: | Macrophage migration inhibitory factor, MIF, Delayed early response protein 6, DER6, Glycosylation-inhibiting factor, GIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase, Glif. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered solution containing 1mM sodium phosphate, pH 7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized MIF in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized MIF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTNDPCALC SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA |
The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.
MIF Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 12.5kDa.The MIF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity |
| UniProt Protein Details: | Catalytic activity: Keto-phenylpyruvate = enol-phenylpyruvate.1 PublicationManual assertion based on experiment in:Ref.12 |
| UniProt Code: | P34884 |
| NCBI GenInfo Identifier: | 6754696 |
| NCBI Gene ID: | 17319 |
| NCBI Accession: | NP_034928.1 |
| UniProt Related Accession: | P34884 |
| Molecular Weight: | 12,504 Da |
| NCBI Full Name: | macrophage migration inhibitory factor |
| NCBI Synonym Full Names: | macrophage migration inhibitory factor |
| NCBI Official Symbol: | Mif�� |
| NCBI Official Synonym Symbols: | GIF; Glif�� |
| NCBI Protein Information: | macrophage migration inhibitory factor; DER6; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase; glycosylation-inhibiting factor; delayed early response protein 6 |
| UniProt Protein Name: | Macrophage migration inhibitory factor |
| UniProt Synonym Protein Names: | Delayed early response protein 6; DER6; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase (EC:5.3.3.12); Phenylpyruvate tautomerase |
| Protein Family: | Macrophage migration inhibitory factor |
| UniProt Gene Name: | Mif�� |
| UniProt Entry Name: | MIF_MOUSE |
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