Description
| Product Name: | Mouse METRN Recombinant Protein |
| Product Code: | RPPB3965 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | METRN |
| Synonyms: | Meteorin, Hypoxia/reoxygenation regulatory factor, Metrn,1810034B16Rik, Hyrac. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | METRN protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GYSEDRCSWRGSGLTQEPGS VGQLTLDCTE GAIEWLYPAG ALRLTLGGPD PGTRPSIVCL RPERPFAGAQ VFAERMTGNLELLLAEGPDL AGGRCMRWGP RERRALFLQA TPHRDISRRV AAFRFELHED QRAEMSPQAQ GLGVDGACRPCSDAELLLAA CTSDFVIHGT IHGVAHDTEL QESVITVVVA RVIRQTLPLF KEGSSEGQGR ASIRTLLRCGVRPGPGSFLF MGWSRFGEAW LGCAPRFQEF SRVYSAALTT HLNPCEMALD HHHHHH |
Meteorin (METRN) is involved in both glial cell differentiation and axonal network formation during neurogenesis. METRN promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Moreover, the METRN protein stimulates axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
METRN produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 276 amino acids (22-291 a.a.) andhaving a molecular mass of 30.2kDa (Migrates at 28-40kDa on SDS-PAGE underreducing conditions).METRN is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | METRN: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. Belongs to the meteorin family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 17|17 A3.3Cellular Component: extracellular spaceBiological Process: glial cell differentiation; positive regulation of axonogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8C1Q4 |
| NCBI GenInfo Identifier: | 51317368 |
| NCBI Gene ID: | 70083 |
| NCBI Accession: | NP_598480.1 |
| UniProt Secondary Accession: | Q8C1Q4,Q45G31, Q6P6N6, Q8CI64, Q922A8 |
| UniProt Related Accession: | Q8C1Q4 |
| Molecular Weight: | 13,797 Da |
| NCBI Full Name: | meteorin |
| NCBI Synonym Full Names: | meteorin, glial cell differentiation regulator |
| NCBI Official Symbol: | Metrn�� |
| NCBI Official Synonym Symbols: | Hyrac; 1810034B16Rik�� |
| NCBI Protein Information: | meteorin |
| UniProt Protein Name: | Meteorin |
| UniProt Synonym Protein Names: | Hypoxia/reoxygenation regulatory factor |
| Protein Family: | Meteorin |
| UniProt Gene Name: | Metrn�� |
| UniProt Entry Name: |
