Enzymes Recombinant Proteins

Mouse MDH2 Recombinant Protein (RPPB1931)

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SKU:
RPPB1931
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P08249
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse MDH2 Recombinant Protein
Product Code:RPPB1931
Size:10µg
Species:Mouse
Target:MDH2
Synonyms:M-MDH, MDH, MOR1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MDH2 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4) and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAKVAVLGAS GGIGQPLSLL LKNSPLVSRL TLYDIAHTPG VAADLSHIET RANVKGYLGP EQLPDCLKGC DVVVIPAGVP RKPGMTRDDL FNTNATIVAT LTAACAQHCP EAMVCIIANP VNSTIPITAE VFKKHGVYNP NKIFGVTTLD IVRANTFVAE LKGLDPARVN VPVIGGHAGK TIIPLISQCT PKVDFPQDQL ATLTGRIQEA GTEVVKAKAG AGSATLSMAY AGARFVFSLV DAMNGKEGVV ECSFVQSKET ECTYFSTPLL LGKKGLEKNL GIGKITPFEE KMIAEAIPEL KASIKKGEDF VKNMK
Biological Activity:Specific activity is > 800 units/mg, and is defined as the amount of enzyme that cleaves 1umole of oxaloacetate and beta-NADH to Lmalate and beta-NAD per minute at pH8.0 at 37�C.

MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and takes part in the malate-aspartate shuttle that functions in the metabolic coordination between cytosol and mitochondria. MDH2 is highy expressed in the adrenal system, small intestine, heart and pancreas.

MDH2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 335 amino acids (25-338a.a.) and having a molecular mass of 35.4kDa. MDH2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
UniProt Code:P08249
NCBI GenInfo Identifier:146345457
NCBI Gene ID:17448
NCBI Accession:P08249.3
UniProt Secondary Accession:P08249,Q0QF44, Q8CF79, Q8R1P0
UniProt Related Accession:P08249
Molecular Weight:35,611 Da
NCBI Full Name:Malate dehydrogenase, mitochondrial
NCBI Synonym Full Names:malate dehydrogenase 2, NAD (mitochondrial)
NCBI Official Symbol:Mdh2��
NCBI Official Synonym Symbols:MDH; Mor1; Mdh-2; Mor-1��
NCBI Protein Information:malate dehydrogenase, mitochondrial
UniProt Protein Name:Malate dehydrogenase, mitochondrial
UniProt Synonym Protein Names:
Protein Family:Malate dehydrogenase
UniProt Gene Name:Mdh2��
UniProt Entry Name:
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