Chemokines Recombinant Proteins
Mouse MDC Recombinant Protein (RPPB1202)
- SKU:
- RPPB1202
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- O88430
- Research Area:
- Chemokines
Description
| Product Name: | Mouse MDC Recombinant Protein |
| Product Code: | RPPB1202 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | MDC |
| Synonyms: | C-C motif chemokine 22, Small-inducible cytokine A22, Macrophage-derived chemokine, MDC(1-69), Stimulated T-cell chemotactic protein 1, CC chemokine STCP-1, CCL22, MDC, SCYA22, ABCD-1, DC/B-CK, MGC34554, A-152E5.1, CC chemokine ABCD-1, Activated B and dendritic cell-derived, DCBCK. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CCL22 filtered (0.2�m) and lyophilized from a concentrated solution containing 20mM phosphate buffer & 150mM NaCl pH-7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized CCL22 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CCL22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL22 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS |
| Biological Activity: | Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4. CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph
CCL22 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. The Mouse CCL22 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity; cytokine activity Biological Process: immune response; inflammatory response; chemotaxis |
| UniProt Code: | O88430 |
| NCBI GenInfo Identifier: | 6094388 |
| NCBI Gene ID: | 20299 |
| NCBI Accession: | O88430.1 |
| UniProt Related Accession: | O88430 |
| Molecular Weight: | 10,302 Da |
| NCBI Full Name: | C-C motif chemokine 22 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 22 |
| NCBI Official Symbol: | Ccl22�� |
| NCBI Official Synonym Symbols: | MDC; DCBCK; ABCD-1; Scya22�� |
| NCBI Protein Information: | C-C motif chemokine 22; CC chemokine ABCD-1; small-inducible cytokine A22; activated B and dendritic cell-derived; small inducible cytokine subfamily A22; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED) |
| UniProt Protein Name: | C-C motif chemokine 22 |
| UniProt Synonym Protein Names: | Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22 |
| UniProt Gene Name: | Ccl22�� |
| UniProt Entry Name: | CCL22_MOUSE |
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