Growth Factors & Cytokines Recombinant Proteins
Mouse MCSF Recombinant Protein (RPPB0754)
- SKU:
- RPPB0754
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P07141
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse MCSF Recombinant Protein |
| Product Code: | RPPB0754 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | MCSF |
| Synonyms: | M-Csf, Macrophage colony-stimulating factor 1, CSF-1, MCSF, Csf1, C87615, MCSF, op, Processedmacrophage colony-stimulating factor 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MCSF solution (1mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPKEVSEHC SHMIGNGHLK VLQQLIDSQM ETSCQIAFEF VDQEQLDDPV CYLKKAFFLVQDIIDETMRF KDNTPNANAT ERLQELSNNL NSCFTKDYEE QNKACVRTFH ETPLQLLEKIKNFFNETKNL LEKDWNIFTK NCNNSFAKCS SRDVVTKPHH HHHH |
| Biological Activity: | Determined by cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. ED50 range for this effect is ? 4ng/ml. |
Macrophage Colony Stimulating Factor (M CSF) or colony stimulating factor 1, is a cytokine, that �promoted differentiation in hematopoietic stem cells to �macrophages. Another role of M CSF is to bind to its receptor (colony stimulating factor 1 receptor) and to� take part in placenta growth and development.
MCSF Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 164 amino acids (33-187 aa) and having a molecular mass of 19.1 kDa.MCSF is fused to a 9 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; extracellular region; integral to membrane; plasma membrane; receptor complex Molecular Function:protein binding; protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; immune system process; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; reproductive developmental process; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; positive regulation of Ras protein signal transduction; regulation of ossification; inflammatory response; positive regulation of macrophage differentiation; positive regulation of cell-matrix adhesion; positive regulation of cell migration |
| UniProt Code: | P07141 |
| NCBI GenInfo Identifier: | 1345843 |
| NCBI Gene ID: | 12977 |
| NCBI Accession: | P07141.2 |
| UniProt Secondary Accession: | P07141,Q3U395, Q8R3C8, |
| UniProt Related Accession: | P07141 |
| Molecular Weight: | 29,353 Da |
| NCBI Full Name: | Macrophage colony-stimulating factor 1 |
| NCBI Synonym Full Names: | colony stimulating factor 1 (macrophage) |
| NCBI Official Symbol: | Csf1�� |
| NCBI Official Synonym Symbols: | op; Csfm; MCSF; C87615�� |
| NCBI Protein Information: | macrophage colony-stimulating factor 1; osteopetrosis |
| UniProt Protein Name: | Macrophage colony-stimulating factor 1 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Csf1�� |
| UniProt Entry Name: | CSF1_MOUSE |
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