Chemokines Recombinant Proteins
Mouse MCP 3 Recombinant Protein (RPPB1195)
- SKU:
- RPPB1195
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q03366
- Research Area:
- Chemokines
Description
| Product Name: | Mouse MCP 3 Recombinant Protein |
| Product Code: | RPPB1195 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | MCP 3 |
| Synonyms: | Small inducible cytokine A7, CCL7, Monocyte chemotactic protein 3, MCP-3, Monocyte chemoattractant protein 3, NC28, chemokine (C-C motif) ligand 7, FIC, MARC, MCP3, SCYA6, SCYA7, MGC138463, MGC138465. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP |
| Biological Activity: | The specific activity as determined by the ability of Mouse MCP-3 to chemoattract Balb/C mouse spleen MNCs at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1).
Monocyte Chemotactic Protein-3 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8510 Dalton. The MCP-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; chemokine activity; CCR2 chemokine receptor binding; cytokine activity Biological Process: immune response; inflammatory response; chemotaxis |
| UniProt Code: | Q03366 |
| NCBI GenInfo Identifier: | 417192 |
| NCBI Gene ID: | 20306 |
| NCBI Accession: | Q03366.1 |
| UniProt Related Accession: | Q03366 |
| Molecular Weight: | 10,999 Da |
| NCBI Full Name: | C-C motif chemokine 7 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 7 |
| NCBI Official Symbol: | Ccl7�� |
| NCBI Official Synonym Symbols: | fic; marc; mcp3; MCP-3; Scya7�� |
| NCBI Protein Information: | C-C motif chemokine 7; RANTES/sis homolog; intercrine/chemokine MARC; small inducible cytokine A7; small-inducible cytokine A7; monocyte chemotactic protein 3; monocyte chemoattractant protein 3 |
| UniProt Protein Name: | C-C motif chemokine 7 |
| UniProt Synonym Protein Names: | Intercrine/chemokine MARC; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; Protein FIC; Small-inducible cytokine A7 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl7�� |
| UniProt Entry Name: | CCL7_MOUSE |
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