Mouse MAP1LC3B Recombinant Protein (RPPB3922)
- SKU:
- RPPB3922
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9CQV6
Description
| Product Name: | Mouse MAP1LC3B Recombinant Protein |
| Product Code: | RPPB3922 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | MAP1LC3B |
| Synonyms: | Microtubule-Associated Protein 1 Light Chain 3 beta, ATG8F, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B LC3 B, LC3B, MAP1A/1BLC3, MAP1ALC3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | MAP1LC3B protein solution (0.25mg/ml) containing 20mM MES(pH6.0), 0.1M NaCl, 1mM DTT and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMPSEKT FKQRRSFEQR VEDVRLIREQ HPTKIPVIIE RYKGEKQLPV LDKTKFLVPD HVNMSELIKI IRRRLQLNAN QAFFLLVNGH SMVSVSTPIS EVYESERDED GFLYMVYASQ ETFG |
MAP1LC3B is a member of the MAP1 LC3 family. MAP1LC3B is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, that are involved in microtubule assembly and important for neurogenesis. In addition, MAP1LC3B takes part in formation of autophagosomal vacuoles and is expressed mainly in heart, testis, brain and skeletal muscle.
MAP1LC3B Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (1-120 a.a.) and having a molecular mass of 16.7kDa.MAP1LC3B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. |
| UniProt Code: | Q9CQV6 |
| NCBI GenInfo Identifier: | 25008770 |
| NCBI Gene ID: | 67443 |
| NCBI Accession: | Q9CQV6.3 |
| UniProt Related Accession: | Q9CQV6 |
| Molecular Weight: | |
| NCBI Full Name: | Microtubule-associated proteins 1A/1B light chain 3B |
| NCBI Synonym Full Names: | microtubule-associated protein 1 light chain 3 beta |
| NCBI Official Symbol: | Map1lc3b�� |
| NCBI Official Synonym Symbols: | Atg8; LC3b; Map1lc3; MAP1A/MAP1B; 1010001C15Rik�� |
| NCBI Protein Information: | microtubule-associated proteins 1A/1B light chain 3B |
| UniProt Protein Name: | Microtubule-associated proteins 1A/1B light chain 3B |
| UniProt Synonym Protein Names: | Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta |
| Protein Family: | Microtubule-associated protein |
| UniProt Gene Name: | Map1lc3b�� |
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