Enzymes Recombinant Proteins
Mouse LYPLA1 Recombinant Protein (RPPB1918)
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- SKU:
- RPPB1918
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P97823
- Research Area:
- Enzymes
Description
| Product Name: | Mouse LYPLA1 Recombinant Protein |
| Product Code: | RPPB1918 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | LYPLA1 |
| Synonyms: | Acyl-protein thioesterase 1, LYPLA1, APT-1, LPL1, LYSOPLA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The LYPLA1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)0.1M NaCl,1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCGNNMSAPM PAVVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIKSPHIK YICPHAPVMP VTLNMNMAMP SWFDIVGLSP DSQEDESGIK QAAETVKALI DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFSQGPINSA NRDISVLQCH GDCDPLVPLM FGSLTVERLK ALINPANVTF KIYEGMMHSS CQQEMMDVKH FIDKLLPPID |
LYPLA1 is lysophospholipase which performs on biological membranes to regulate the multifunctional lysophospholipids. LYPLA1 protein hydrolyzes fatty acids from S-acylated cysteine residues in proteins like trimeric G alpha proteins or HRAS and in addition has depalmitoylating activity.
LYPLA1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-230a.a.) and having a molecular mass of 26.8kDa.LYPLA1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.2.-; Lipid Metabolism - glycerophospholipid; Mitochondrial; PhospholipaseChromosomal Location of Human Ortholog: 1|1 A1Cellular Component: cytosol; mitochondrionMolecular Function: lipase activity; lysophospholipase activity; palmitoyl-(protein) hydrolase activityBiological Process: negative regulation of Golgi to plasma membrane protein transport; protein depalmitoylation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P97823 |
| NCBI GenInfo Identifier: | 6678760 |
| NCBI Gene ID: | 18777 |
| NCBI Accession: | NP_032892.1 |
| UniProt Secondary Accession: | P97823,Q3TJZ0, Q7TPX1, Q8BWM6 |
| UniProt Related Accession: | P97823 |
| Molecular Weight: | 52.1kD |
| NCBI Full Name: | acyl-protein thioesterase 1 |
| NCBI Synonym Full Names: | lysophospholipase 1 |
| NCBI Official Symbol: | Lypla1�� |
| NCBI Official Synonym Symbols: | Pla1a�� |
| NCBI Protein Information: | acyl-protein thioesterase 1 |
| UniProt Protein Name: | Acyl-protein thioesterase 1 |
| UniProt Synonym Protein Names: | Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I |
| Protein Family: | Acyl-protein thioesterase |
| UniProt Gene Name: | Lypla1�� |
| UniProt Entry Name: |
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