Mouse LUM Recombinant Protein (RPPB5903)

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RPPB5903

Description

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Product Name:Mouse LUM Recombinant Protein
Product Code:RPPB5903
Size:10µg
Species:Mouse
Target:LUM
Synonyms:Lum, Ldc, SLRR2D, Lumican, Keratan sulfate proteoglycan lumican, KSPG lumican.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LUM protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:QYYDYDIPLF MYGQISPNCA PECNCPHSYP TAMYCDDLKL KSVPMVPPGI KYLYLRNNQIDHIDEKAFEN VTDLQWLILD LLENSKIK GKVFSKLKQL KKLHINYNNL TESVGPLPKSLQDLQLTNNK ISKLGSFDGL VNLTFIYLQH NQLKEDAVSA SLKGLKSLEY LDLSFNQMSKLPAGLPTSLL TLYLDNNKIS NIPDEYFKRF TGLQYLRLSH NELADSGVPG NSFNISSLLELDLSYNKLKS IPTVNENLEN YYLEVNELEK FDVKSFCKIL GPLSYSKIKH LRLDGNPLTQ SSLPPDMYEC LRVANEITVN VEHHHHHH

Lumican also known as LUM is a part of the small leucine-rich proteoglycan (SLRP) family which comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Furthermore, we can see that in these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagen fibril organization and circumferential growth, corneal transparency, epithelial cell migration and tissue repair.

LUM Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 328 amino acids (19-338 a.a) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).LUM is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; fibrillar collagen; extracellular region

Molecular Function:collagen binding

Biological Process: collagen fibril organization; visual perception; positive regulation of transcription from RNA polymerase II promoter

UniProt Code:P51885
NCBI GenInfo Identifier:21542415
NCBI Gene ID:17022
NCBI Accession:P51885.2
UniProt Secondary Accession:P51885,Q3TP25, Q99JZ3, Q9CXK0,
UniProt Related Accession:P51885
Molecular Weight:38,265 Da
NCBI Full Name:Lumican
NCBI Synonym Full Names:lumican
NCBI Official Symbol:Lum��
NCBI Official Synonym Symbols:Ldc; SLRR2D��
NCBI Protein Information:lumican; KSPG lumican; keratan sulfate proteoglycan lumican
UniProt Protein Name:Lumican
UniProt Synonym Protein Names:Keratan sulfate proteoglycan lumican; KSPG lumican
Protein Family:Lumican
UniProt Gene Name:Lum��
UniProt Entry Name:LUM_MOUSE
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P51885
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