Enzymes Recombinant Proteins

Mouse LCN2 Recombinant Protein (RPPB1891)

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SKU:
RPPB1891
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P11672
Research Area:
Enzymes

Description

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Product Name:Mouse LCN2 Recombinant Protein
Product Code:RPPB1891
Size:20µg
Species:Mouse
Target:LCN2
Synonyms:Neutrophil gelatinase-associated lipocalin, NGAL,Lipocalin-2, SV-40-induced 24P3 protein, Siderocalin LCN2, p25.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LCN2 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQDSTQNL IPAPSLLTVP LQPDFRSDQF RGRWYVVGLA GNAVQKKTEGSFTMYSTIYE LQENNSYNVT SILVRDQDQG CRYWIRTFVP SSRAGQFTLG NMHRYPQVQS YNVQVATTDYNQFAMVFFRK TSENKQYFKI TLYGRTKELS PELKERFTRF AKSLGLKDDN IIFSVPTDQC IDN

Lipocalin-2 also called Neutrophil Gelatinase Associated Lipocalin (NGAL) belongs to a family of lipocans which include 25 proteins (including a1-microglobulin and b-lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core.They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke.

LCN2 Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 203 amino acids (21-200 a.a) andhaving a molecular mass of 23.3kDa.�LCN2 is fused to a 23 aminoacid His-tag at N-terminus & purified by proprietary chromatographictechniques.

UniProt Protein Function:LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function:protein binding; protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to drug; iron ion homeostasis; immune system process; transport; apoptosis; response to virus; siderophore transport; positive regulation of cell projection organization and biogenesis; innate immune response; ion transport; response to herbicide

UniProt Code:P11672
NCBI GenInfo Identifier:112725
NCBI Gene ID:16819
NCBI Accession:P11672.1
UniProt Secondary Accession:P11672,Q3UE34,
UniProt Related Accession:P11672
Molecular Weight:22,875 Da
NCBI Full Name:Neutrophil gelatinase-associated lipocalin
NCBI Synonym Full Names:lipocalin 2
NCBI Official Symbol:Lcn2��
NCBI Official Synonym Symbols:24p3; Sip24; AW212229��
NCBI Protein Information:neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; siderocalin LCN2; SV-40-induced 24P3 protein; secreted inducible protein 24
UniProt Protein Name:Neutrophil gelatinase-associated lipocalin
UniProt Synonym Protein Names:Lipocalin-2; SV-40-induced 24P3 protein; Siderocalin LCN2; p25
Protein Family:Neutrophil gelatinase-associated lipocalin
UniProt Gene Name:Lcn2��
UniProt Entry Name:NGAL_MOUSE
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