Chemokines Recombinant Proteins
Mouse IP 10 Recombinant Protein (RPPB1172)
- SKU:
- RPPB1172
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P17515
- Research Area:
- Chemokines
Description
| Product Name: | Mouse IP 10 Recombinant Protein |
| Product Code: | RPPB1172 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | IP 10 |
| Synonyms: | Small inducible cytokine B10, CXCL10, 10 kDa, Gamma-IP10, IP-10, chemokine (C-X-C motif) ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IP-10 was lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IP-10 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP |
| Biological Activity: | Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 100.0-500.0 ng/ml. |
Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.
IP-10 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8701 Dalton. The IP-10 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane Molecular Function:heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity Biological Process: response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of myoblast differentiation; defense response to virus; positive regulation of cell migration |
| UniProt Code: | P17515 |
| NCBI GenInfo Identifier: | 124494 |
| NCBI Gene ID: | 15945 |
| NCBI Accession: | P17515.1 |
| UniProt Related Accession: | P17515 |
| Molecular Weight: | 10,789 Da |
| NCBI Full Name: | C-X-C motif chemokine 10 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 10 |
| NCBI Official Symbol: | Cxcl10�� |
| NCBI Official Synonym Symbols: | C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10�� |
| NCBI Protein Information: | C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10 |
| UniProt Protein Name: | C-X-C motif chemokine 10 |
| UniProt Synonym Protein Names: | 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10 |
| UniProt Gene Name: | Cxcl10�� |
| UniProt Entry Name: | CXL10_MOUSE |
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