Mouse Interleukin3/IL3 Recombinant Protein (RPES1606)
- SKU:
- RPES1606
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse Interleukin3/IL3 Recombinant Protein
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13R?1 with low affinity and triggers association of IL4R?, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13R?2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
| Product Name: | Mouse Interleukin3/IL3 Recombinant Protein (RPES1606) |
| Product Code: | RPES1606 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-13, IL-13, T-Cell Activation Protein P600, Il13, Il-13 |
| Accession: | P20109 |
| Sequence: | Ser26-Phe131 |
| Fusion tag: | C-6His |
| Activity: | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 2-13 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse Interleukin-13 is produced by our Mammalian expression system and the target gene encoding Ser26-Phe131 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 12.7 kDa |
| AP Mol Mass: | 15-30 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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