Cytokines Recombinant Proteins

Mouse IL6R Recombinant Protein (RPPB0535)

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RPPB0535
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Product Name:Mouse IL6R Recombinant Protein
Product Code:RPPB0535
Size:10µg
Species:Mouse
Target:IL6R
Synonyms:IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha,CD130.
Source:Sf9 Insect cells
Physical Appearance:Sterilefiltered colorless solution.
Formulation: IL6R protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence: QLLEPCGYIY PEFPVVQRGS NFTAICVLKE ACLQHYYVNA SYIVWKTNHA AVPREQVTVI NRTTSSVTFT DVVLPSVQLT CNILSFGQIE QNVYGVTMLS GFPPDKPTNL TCIVNEGKNM LCQWDPGRET YLETNYTLKS EWATEKFPDC QSKHGTSCMV SYMPTYYVNI EVWVEAENAL GKVSSESINF DPVDKVKPTP PYNLSVTNSE ELSSILKLSW VSSGLGGLLD LKSDIQYRTK DASTWIQVPL EDTMSPRTSF TVQDLKPFTE YVFRIRSIKD SGKGYWSDWS EEASGTTYED RPSRPPSFWY KTNPSHGQEY RSVRLIWKAL PLSEANGKIL DYEVILTQSK SVSQTYTVTG TELTVNLTND RYVASLAARN KVGKSAAAVL TIPSPHVTAA YSVVNLKAFP KDNLLWVEWT PPPKPVSKYI LEWCVLSENA PCVEDWQQED ATVNRTHLRG RLLESKCYQI TVTPVFATGP GGSESLKAYL KQAAPARGPT VRTKKVGKNE AVLAWDQIPV DDQNGFIRNY SISYRTSVGK EMVVHVDSSH TEYTLSSLSSDTLYMVRMAA YTDEGGKDGP EFTFTTPKFA QGEIELEHHH HHH

The IL-6 receptor complex is composed of two membrane glycoproteins: the low affinity receptor and the signaltransducing component. The soluble form of IL6R is found in the urine of healthy adult humans and the serum of HIV positive individuals, as well as in the cell culture supernatants of stimulated PBMC�s. This soluble form of IL6R results from either proteolytic cleavage from the membrane, or an isoform derived splice variant.

IL6R produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 603 amino acids (23-617a.a.) and having a molecular mass of 67.7kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).IL6R is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.Protein type: Membrane protein, integral; Receptor, cytokineCellular Component: extracellular space; membrane; cell soma; oncostatin-M receptor complex; dendrite; integral to membrane; interleukin-6 receptor complex; cytosol; external side of plasma membraneMolecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 binding; protein binding; interleukin-6 receptor binding; interleukin-6 binding; leukemia inhibitory factor receptor activity; protein heterodimerization activity; oncostatin-M receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; ciliary neurotrophic factor receptor binding; interleukin-11 receptor activityBiological Process: glycogen metabolic process; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of smooth muscle cell migration; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; response to cytokine stimulus; reduction of cytosolic calcium ion concentration; positive regulation of cell proliferation; positive regulation of T cell proliferation; triacylglycerol mobilization; positive regulation of astrocyte differentiation
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q00560
NCBI GenInfo Identifier:408360148
NCBI Gene ID:16195
NCBI Accession:Q00560.2
UniProt Secondary Accession:Q00560,G5E8D2
UniProt Related Accession:Q00560
Molecular Weight:102,451 Da
NCBI Full Name:Interleukin-6 receptor subunit beta
NCBI Synonym Full Names:interleukin 6 signal transducer
NCBI Official Symbol:Il6st��
NCBI Official Synonym Symbols:CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik��
NCBI Protein Information:interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha
UniProt Protein Name:Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names:Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
Protein Family:Interleukin-6 receptor
UniProt Gene Name:Il6st��
UniProt Entry Name:IL6RB_MOUSE
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q00560
Research Area:
Cytokines
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